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      PEGylated calix[4]arene as a carrier for a Bodipy-based photosensitizer

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      Author
      Cakmak, Y.
      Nalbantoglu, T.
      Durgut, T.
      Akkaya, E. U.
      Date
      2014
      Source Title
      Tetrahedron Letters
      Print ISSN
      0040-4039
      Electronic ISSN
      1873-3581
      Publisher
      Elsevier
      Volume
      55
      Issue
      2
      Pages
      538 - 540
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Heavy atom substituted Bodipy compounds, unlike the parent chromophore, undergo rapid intersystem crossing to generate singlet oxygen, which is the primary cytotoxic agent exploited in PDT. In this work, we show that an organic soluble calix[4]arene can be functionalized by Knoevenagel reaction and then converted into an amphiphilic photosensitizer in a few steps. In addition to generating a potentially useful photosensitizer, the sequence of reactions is the first use of a Bodipy dye as a chromophoric/fluorogenic label without the typical reactive functional groups.
      Keywords
      Bodipy
      Calixarenes
      PDT
      Photosensitizers
      Singlet oxygen
      Permalink
      http://hdl.handle.net/11693/26370
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.tetlet.2013.11.083
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