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      Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action

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      Author
      Turan, I. S.
      Cakmak, F. P.
      Yildirim, D. C.
      Cetin Atalay, R.
      Akkaya, E. U.
      Date
      2014
      Source Title
      Chemistry: A European Journal
      Print ISSN
      0947-6539
      Electronic ISSN
      1521-3765
      Publisher
      Wiley-VCH Verlag
      Volume
      20
      Issue
      49
      Pages
      16088 - 16092
      Language
      English
      Type
      Article
      Item Usage Stats
      131
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      137
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      Abstract
      Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.
      Keywords
      BODIPY dyes
      Photochemistry
      Photodynamic action
      Photosensitizers
      Singlet oxygen
      Cell culture
      Dissolved oxygen
      Molecular oxygen
      Peptides
      Photochemical reactions
      Photodynamic therapy
      Bodipy dyes
      Cancer cells
      Cytotoxic
      Glutathione concentration
      Glutathiones
      Near-IR
      Photodynamic action
      Singlet oxygen
      Photosensitizers
      Permalink
      http://hdl.handle.net/11693/26369
      Published Version (Please cite this version)
      http://dx.doi.org/10.1002/chem.201405450
      Collections
      • Department of Chemistry 594
      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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