Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action
Author
Turan, I. S.
Cakmak, F. P.
Yildirim, D. C.
Cetin Atalay, R.
Akkaya, E. U.
Date
2014Source Title
Chemistry: A European Journal
Print ISSN
0947-6539
Electronic ISSN
1521-3765
Publisher
Wiley-VCH Verlag
Volume
20
Issue
49
Pages
16088 - 16092
Language
English
Type
ArticleItem Usage Stats
131
views
views
137
downloads
downloads
Abstract
Enhanced spatiotemporal selectivity in photonic
sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical
applications of photodynamic therapy. Considering the
high intracellular glutathione concentrations within cancer
cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed
and synthesized. Cell culture studies not only validate our
design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of
the photosensitizer.
Keywords
BODIPY dyesPhotochemistry
Photodynamic action
Photosensitizers
Singlet oxygen
Cell culture
Dissolved oxygen
Molecular oxygen
Peptides
Photochemical reactions
Photodynamic therapy
Bodipy dyes
Cancer cells
Cytotoxic
Glutathione concentration
Glutathiones
Near-IR
Photodynamic action
Singlet oxygen
Photosensitizers