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dc.contributor.authorUzunalli, G.en_US
dc.contributor.authorSoran, Z.en_US
dc.contributor.authorErkal, T. S.en_US
dc.contributor.authorDagdas, Y. S.en_US
dc.contributor.authorDinc, E.en_US
dc.contributor.authorHondur, A. M.en_US
dc.contributor.authorBilgihan, K.en_US
dc.contributor.authorAydin B.en_US
dc.contributor.authorGuler, M. O.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.date.accessioned2016-02-08T10:58:13Z
dc.date.available2016-02-08T10:58:13Z
dc.date.issued2014en_US
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/11693/26316
dc.description.abstractDefects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential for treatment of these defects. This paper describes a bioactive peptide nanofiber scaffold system for corneal tissue regeneration. These nanofibers are formed by self-assembling peptide amphiphile molecules containing laminin and fibronectin inspired sequences. Human corneal keratocyte cells cultured on laminin-mimetic peptide nanofibers retained their characteristic morphology, and their proliferation was enhanced compared with cells cultured on fibronectin-mimetic nanofibers. When these nanofibers were used for damaged rabbit corneas, laminin-mimetic peptide nanofibers increased keratocyte migration and supported stroma regeneration. These results suggest that laminin-mimetic peptide nanofibers provide a promising injectable, synthetic scaffold system for cornea stroma regeneration.en_US
dc.language.isoEnglishen_US
dc.source.titleActa Biomaterialiaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.actbio.2013.12.002en_US
dc.subjectCorneal stroma regenerationen_US
dc.subjectPeptide amphiphileen_US
dc.subjectRGDen_US
dc.subjectSelf-assemblyen_US
dc.subjectYIGSRen_US
dc.subjectBiomaterialen_US
dc.subjectNanofiberen_US
dc.subjectPeptideen_US
dc.subjectSurfactanten_US
dc.subjectAmino acid sequenceen_US
dc.subjectAnimalen_US
dc.subjectCell cultureen_US
dc.subjectCell proliferationen_US
dc.subjectCell shapeen_US
dc.subjectChemistryen_US
dc.subjectCornea stromaen_US
dc.subjectCytologyen_US
dc.subjectDrug effectsen_US
dc.subjectFibroblasten_US
dc.subjectHumanen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMolecular geneticsen_US
dc.subjectPhysiologyen_US
dc.subjectRabbiten_US
dc.subjectRegenerationen_US
dc.subjectUltrastructureen_US
dc.subjectAmino Acid Sequenceen_US
dc.subjectAnimalsen_US
dc.subjectBiocompatible Materialsen_US
dc.subjectCell Proliferationen_US
dc.subjectCell Shapeen_US
dc.subjectCells, Cultureden_US
dc.subjectCorneal Stromaen_US
dc.subjectFibroblastsen_US
dc.subjectHumansen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMolecular Sequence Dataen_US
dc.subjectNanofibersen_US
dc.subjectPeptidesen_US
dc.subjectRabbitsen_US
dc.subjectRegenerationen_US
dc.subjectSurface-Active Agentsen_US
dc.titleBioactive self-assembled peptide nanofibers for corneal stroma regenerationen_US
dc.typeArticleen_US
dc.departmentInstitute of Materials Science and Nanotechnologyen_US
dc.departmentNanotechnology Research Centeren_US
dc.citation.spage1156en_US
dc.citation.epage1166en_US
dc.citation.volumeNumber10en_US
dc.citation.issueNumber3en_US
dc.identifier.doi10.1016/j.actbio.2013.12.002en_US
dc.publisherElsevieren_US


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