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dc.contributor.authorUzunallı, Gözdeen_US
dc.contributor.authorSoran, Zeliha Soranen_US
dc.contributor.authorErkal, Turan S.en_US
dc.contributor.authorDagdas, Yavuz Sen_US
dc.contributor.authorDinc, E.en_US
dc.contributor.authorHondur, A. M.en_US
dc.contributor.authorBilgihan, K.en_US
dc.contributor.authorAydin B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, Ayşe B.en_US
dc.date.accessioned2016-02-08T10:58:13Z
dc.date.available2016-02-08T10:58:13Z
dc.date.issued2014en_US
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/11693/26316
dc.description.abstractDefects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential for treatment of these defects. This paper describes a bioactive peptide nanofiber scaffold system for corneal tissue regeneration. These nanofibers are formed by self-assembling peptide amphiphile molecules containing laminin and fibronectin inspired sequences. Human corneal keratocyte cells cultured on laminin-mimetic peptide nanofibers retained their characteristic morphology, and their proliferation was enhanced compared with cells cultured on fibronectin-mimetic nanofibers. When these nanofibers were used for damaged rabbit corneas, laminin-mimetic peptide nanofibers increased keratocyte migration and supported stroma regeneration. These results suggest that laminin-mimetic peptide nanofibers provide a promising injectable, synthetic scaffold system for cornea stroma regeneration.en_US
dc.language.isoEnglishen_US
dc.source.titleActa Biomaterialiaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.actbio.2013.12.002en_US
dc.subjectCorneal stroma regenerationen_US
dc.subjectPeptide amphiphileen_US
dc.subjectCorneal stroma regenerationen_US
dc.subjectYIGSRen_US
dc.subjectRGDen_US
dc.subjectPeptide amphiphileen_US
dc.subjectSelf-assemblyen_US
dc.titleBioactive self-assembled peptide nanofibers for corneal stroma regenerationen_US
dc.typeArticleen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.citation.spage1156en_US
dc.citation.epage1166en_US
dc.citation.volumeNumber10en_US
dc.citation.issueNumber3en_US
dc.identifier.doi10.1016/j.actbio.2013.12.002en_US
dc.publisherElsevieren_US
dc.contributor.bilkentauthorUzunallı, Gözde
dc.contributor.bilkentauthorSoran, Zeliha Soran
dc.contributor.bilkentauthorErkal, Turan S.
dc.contributor.bilkentauthorDagdas, Yavuz S
dc.contributor.bilkentauthorGüler, Mustafa O.
dc.contributor.bilkentauthorTekinay, Ayşe B.


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