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      Bioactive self-assembled peptide nanofibers for corneal stroma regeneration

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      Author
      Uzunallı, Gözde
      Soran, Zeliha Soran
      Erkal, Turan S.
      Dagdas, Yavuz S
      Dinc, E.
      Hondur, A. M.
      Bilgihan, K.
      Aydin B.
      Güler, Mustafa O.
      Tekinay, Ayşe B.
      Date
      2014
      Source Title
      Acta Biomaterialia
      Print ISSN
      1742-7061
      Publisher
      Elsevier
      Volume
      10
      Issue
      3
      Pages
      1156 - 1166
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential for treatment of these defects. This paper describes a bioactive peptide nanofiber scaffold system for corneal tissue regeneration. These nanofibers are formed by self-assembling peptide amphiphile molecules containing laminin and fibronectin inspired sequences. Human corneal keratocyte cells cultured on laminin-mimetic peptide nanofibers retained their characteristic morphology, and their proliferation was enhanced compared with cells cultured on fibronectin-mimetic nanofibers. When these nanofibers were used for damaged rabbit corneas, laminin-mimetic peptide nanofibers increased keratocyte migration and supported stroma regeneration. These results suggest that laminin-mimetic peptide nanofibers provide a promising injectable, synthetic scaffold system for cornea stroma regeneration.
      Keywords
      Corneal stroma regeneration
      Peptide amphiphile
      Corneal stroma regeneration
      YIGSR
      RGD
      Peptide amphiphile
      Self-assembly
      Permalink
      http://hdl.handle.net/11693/26316
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.actbio.2013.12.002
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 197
      • Institute of Materials Science and Nanotechnology (UNAM) 1875
      • Nanotechnology Research Center (NANOTAM) 1043
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