Bioactive self-assembled peptide nanofibers for corneal stroma regeneration
Author
Uzunallı, Gözde
Soran, Zeliha Soran
Erkal, Turan S.
Dagdas, Yavuz S
Dinc, E.
Hondur, A. M.
Bilgihan, K.
Aydin B.
Güler, Mustafa O.
Tekinay, Ayşe B.
Date
2014Source Title
Acta Biomaterialia
Print ISSN
1742-7061
Publisher
Elsevier
Volume
10
Issue
3
Pages
1156 - 1166
Language
English
Type
ArticleItem Usage Stats
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Abstract
Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential for treatment of these defects. This paper describes a bioactive peptide nanofiber scaffold system for corneal tissue regeneration. These nanofibers are formed by self-assembling peptide amphiphile molecules containing laminin and fibronectin inspired sequences. Human corneal keratocyte cells cultured on laminin-mimetic peptide nanofibers retained their characteristic morphology, and their proliferation was enhanced compared with cells cultured on fibronectin-mimetic nanofibers. When these nanofibers were used for damaged rabbit corneas, laminin-mimetic peptide nanofibers increased keratocyte migration and supported stroma regeneration. These results suggest that laminin-mimetic peptide nanofibers provide a promising injectable, synthetic scaffold system for cornea stroma regeneration.
Keywords
Corneal stroma regenerationPeptide amphiphile
Corneal stroma regeneration
YIGSR
RGD
Peptide amphiphile
Self-assembly