Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers
Colloids and Surfaces B: Biointerfaces
15 - 21
Item Usage Stats
In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form inclusion complex (NAP-βCD-IC) and then NAP-βCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-βCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-βCD-IC and the presence of CD-IC in PCL/NAP-βCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-βCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300. nm, in addition, the aggregates of CD-IC in PCL/NAP-βCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-βCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.
Average fiber diameters
Beta cyclodextrin derivative
Drug delivery system
Proton nuclear magnetic resonance
Scanning electron microscopy
X ray diffraction
High performance liquid chromatography
Nuclear magnetic resonance spectroscopy
Chromatography, High Pressure Liquid
Drug Delivery Systems
Magnetic Resonance Spectroscopy
Spectroscopy, Fourier Transform Infrared
Published Version (Please cite this version)http://dx.doi.org/10.1016/j.colsurfb.2013.11.021
Showing items related by title, author, creator and subject.
Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers Aytaç, Zeynep; Uyar, Tamer (Elsevier, 2016-06)Cyclodextrin inclusion complexes (CD-ICs) can be encapsulated into electrospun nanofibers in order to achieve delivery systems having high surface area and highly porous nanofibrous structures. In this study, a well-known ...
Electrospinning of cyclodextrin functional nanofibers for drug delivery applications Topuz, Fuat; Uyar, Tamer (MDPI AG, 2019)Electrospun nanofibers have sparked tremendous attention in drug delivery since they can offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred protein adsorption, and tunable ...
Fast-dissolving antibacterial nanofibers of cyclodextrin/antibiotic inclusion complexes for oral drug delivery Topuz, F.; Kılıç, M. E.; Durgun, Engin (Elsevier, 2020)Hypothesis The widespread use of antibacterial electrospun nanofibers is mostly restricted due to their low loading capacity to carry antibiotics and the need to use toxic organic solvents to boost the antibiotic loading ...