Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers
Canbolat, M. F.
Colloids and Surfaces B: Biointerfaces
15 - 21
Item Usage Stats
MetadataShow full item record
In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form inclusion complex (NAP-βCD-IC) and then NAP-βCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-βCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-βCD-IC and the presence of CD-IC in PCL/NAP-βCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-βCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300. nm, in addition, the aggregates of CD-IC in PCL/NAP-βCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-βCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.
Average fiber diameters
Beta cyclodextrin derivative
Drug delivery system
Proton nuclear magnetic resonance
Scanning electron microscopy
X ray diffraction
High performance liquid chromatography
Nuclear magnetic resonance spectroscopy
Chromatography, High Pressure Liquid
Drug Delivery Systems
Magnetic Resonance Spectroscopy
Spectroscopy, Fourier Transform Infrared
Published Version (Please cite this version)http://dx.doi.org/10.1016/j.colsurfb.2013.11.021
Showing items related by title, author, creator and subject.
Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers Aytac Z.; Uyar T. (Elsevier, 2016-06)Cyclodextrin inclusion complexes (CD-ICs) can be encapsulated into electrospun nanofibers in order to achieve delivery systems having high surface area and highly porous nanofibrous structures. In this study, a well-known ...
Aytaç, Zeynep (Bilkent University, 2016-09)Electrospinning is a widely used versatile method to produce nanofibers with high surface to volume ratio and porous structure. Owing to the unique properties, electrospun nanofibers are of great importance as a carrier ...
Bacteria immobilized electrospun polycaprolactone and polylactic acid fibrous webs for remediation of textile dyes in water Sarioglu O.F.; S. Keskin, N. O.; Celebioglu A.; Tekinay, T.; Uyar T. (Elsevier, 2017-10)In this study, preparation and application of novel biocomposite materials for textile dye removal which are produced by immobilization of specific bacteria onto electrospun nanofibrous webs are presented. A textile dye ...