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      Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers

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      Author(s)
      Canbolat, M. F.
      Celebioglu A.
      Uyar, Tamer
      Date
      2014
      Source Title
      Colloids and Surfaces B: Biointerfaces
      Print ISSN
      0927-7765
      Publisher
      Elsevier
      Volume
      115
      Pages
      15 - 21
      Language
      English
      Type
      Article
      Item Usage Stats
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      699
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      Abstract
      In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form inclusion complex (NAP-βCD-IC) and then NAP-βCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-βCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-βCD-IC and the presence of CD-IC in PCL/NAP-βCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-βCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300. nm, in addition, the aggregates of CD-IC in PCL/NAP-βCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-βCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.
      Keywords
      Cyclodextrin
      Drug
      Inclusion complex
      Nanofibers
      Naproxen
      Release
      Cyclodextrins
      Drug delivery
      Polycaprolactone
      Average fiber diameters
      Drug
      Drug-delivery systems
      Inclusion complex
      Naproxens
      Poly(ecaprolactone) (PCL)
      Release
      Solubility enhancement
      Nanofibers
      Beta cyclodextrin
      Buffer
      Nanofiber
      Naproxen
      Polycaprolactone
      Polycaprolactone nanofiber
      Unclassified drug
      Beta cyclodextrin
      Beta cyclodextrin derivative
      Nanofiber
      Naproxen
      Polycaprolactone
      Polyester
      Article
      Complex formation
      Controlled study
      Drug delivery system
      Drug release
      Drug solubility
      Electrospinning
      Infrared spectroscopy
      Particle size
      Physical chemistry
      Priority journal
      Proton nuclear magnetic resonance
      Scanning electron microscopy
      Thermogravimetry
      X ray diffraction
      Chemistry
      High performance liquid chromatography
      Nuclear magnetic resonance spectroscopy
      Procedures
      Solubility
      Tissue engineering
      Ultrastructure
      Ultraviolet spectrophotometry
      Beta-Cyclodextrins
      Chromatography, High Pressure Liquid
      Drug Delivery Systems
      Magnetic Resonance Spectroscopy
      Nanofibers
      Naproxen
      Polyesters
      Solubility
      Spectrophotometry, Ultraviolet
      Spectroscopy, Fourier Transform Infrared
      Thermogravimetry
      Tissue Engineering
      X-Ray Diffraction
      Permalink
      http://hdl.handle.net/11693/26315
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.colsurfb.2013.11.021
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2260
      • Nanotechnology Research Center (NANOTAM) 1179
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