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      Noncovalent functionalization of mesoporous silica nanoparticles with amphiphilic peptides

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      Author(s)
      Sardan, M.
      Yildirim, A.
      Mumcuoglu, D.
      Tekinay, A. B.
      Güler, Mustafa O.
      Date
      2014
      Source Title
      Journal of Materials Chemistry B
      Print ISSN
      20507518
      Publisher
      Royal Society of Chemistry
      Volume
      2
      Issue
      15
      Pages
      2168 - 2174
      Language
      English
      Type
      Article
      Item Usage Stats
      132
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      107
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      Abstract
      The surface of mesoporous silica nanoparticles (MSNs) has been modified for enhancing their cellular uptake, cell targeting, bioimaging, and controlled drug release. For this purpose, covalent anchorage on the silica surface was predominantly exploited with a wide range of bioactive molecules. Here, we describe a facile self-assembly method to prepare a hybrid peptide silica system composed of octyl-modified mesoporous silica nanoparticles (MSNs) and peptide amphiphiles (PAs). The hydrophobic organosilane surface of mesoporous silica was coated with amphiphilic peptide molecules. The peptide functionalized particles exhibited good cyto-compatibility with vascular smooth muscle and vascular endothelial cells. The peptide coating also improved the cellular uptake of particles up to 6.3 fold, which is promising for the development of highly efficient MSN based theranostic agents. © 2014 the Partner Organisations.
      Keywords
      Amphiphilic peptides
      Controlled drug release
      Functionalized particles
      Mesoporous silica nanoparticles
      Non-covalent functionalization
      Self-assembly method
      Vascular endothelial cells
      Vascular smooth muscles
      Endothelial cells
      Polymer blends
      Silica
      Peptides
      Permalink
      http://hdl.handle.net/11693/26191
      Published Version (Please cite this version)
      https://doi.org/10.1039/c4tb00037d
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
      • Nanotechnology Research Center (NANOTAM) 1063
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