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      Spectroscopic evaluation of DNA–borate Interactions

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      Author(s)
      Ozdemir, A.
      Sarioglu O. F.
      Tekinay, T.
      Date
      2015
      Source Title
      Biological Trace Element Research
      Print ISSN
      0163-4984
      Publisher
      Humana Press Inc.
      Volume
      168
      Issue
      2
      Pages
      508 - 515
      Language
      English
      Type
      Article
      Item Usage Stats
      127
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      150
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      Abstract
      We describe the binding characteristics of two natural borates (colemanite and ulexite) to calf thymus DNA by UV–vis absorbance spectroscopy, circular dichroism (CD) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, and a competitive DNA binding assay. Our results suggest that colemanite and ulexite interact with calf thymus DNA under a non-intercalative mode of binding and do not alter the secondary structure of the DNA helix. The FT-IR spectroscopy results indicate that the two borates might interact with DNA through sugar-phosphate backbone binding. © 2015, Springer Science+Business Media New York.
      Keywords
      Boron
      Calf thymus DNA
      Deoxyribose sugar
      DNA binding
      Spectroscopy
      Boric acid
      Colemanite
      DNA
      Sugar phosphate
      Ulexite
      Unclassified drug
      Chemical structure
      Circular dichroism
      Competitive binding assay
      Controlled study
      DNA helix
      DNA structure
      Infrared spectroscopy
      Interactions with DNA
      Ultraviolet spectroscopy
      Permalink
      http://hdl.handle.net/11693/26146
      Published Version (Please cite this version)
      https://doi.org/10.1007/s12011-015-0369-5
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
      • Nanotechnology Research Center (NANOTAM) 1063
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