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      Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers

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      Author
      Aytac Z.
      Dogan, S.Y.
      Tekinay, T.
      Uyar, Tamer
      Date
      2014
      Source Title
      Colloids and Surfaces B: Biointerfaces
      Print ISSN
      0927-7765
      Publisher
      Elsevier
      Volume
      120
      Pages
      125 - 131
      Language
      English
      Type
      Article
      Item Usage Stats
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      184
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      Abstract
      Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. © 2014 Elsevier B.V.
      Keywords
      Allyl isothiocyanate
      Antibacterial activity
      Electrospinning
      Nanofibers
      Release
      β-Cyclodextrin
      Bacteria
      Cyclodextrins
      Electrospinning
      Escherichia coli
      Allyl isothiocyanate
      Anti-bacterial activity
      Cyclodextrin complexes
      Electrospinning process
      Electrospun nanofibers
      Inclusion complexation
      Poly (vinyl alcohol) (PVA)
      Release
      Nanofibers
      allyl isothiocyanate
      beta cyclodextrin
      nanofiber
      polyvinyl alcohol
      allyl isothiocyanate
      antiinfective agent
      beta cyclodextrin
      beta cyclodextrin derivative
      isothiocyanic acid derivative
      nanofiber
      solution and solubility
      article
      bactericidal activity
      bacterium colony
      complex formation
      concentration (parameters)
      controlled study
      crystal structure
      electrospinning
      Escherichia coli
      evaporation
      mass fragmentography
      nanoencapsulation
      nonhuman
      priority journal
      proton nuclear magnetic resonance
      scanning electron microscopy
      Staphylococcus aureus
      tensile strength
      bacterial count
      chemistry
      drug effects
      drug release
      growth, development and aging
      microbial sensitivity test
      nanotechnology
      procedures
      solution and solubility
      ultrastructure
      X ray diffraction
      Anti-Bacterial Agents
      beta-Cyclodextrins
      Colony Count, Microbial
      Drug Liberation
      Escherichia coli
      Isothiocyanates
      Microbial Sensitivity Tests
      Nanofibers
      Nanotechnology
      Proton Magnetic Resonance Spectroscopy
      Solutions
      Staphylococcus aureus
      X-Ray Diffraction
      Permalink
      http://hdl.handle.net/11693/25569
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.colsurfb.2014.04.006
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