Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers
Colloids and Surfaces B: Biointerfaces
125 - 131
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Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. © 2014 Elsevier B.V.
Poly (vinyl alcohol) (PVA)
beta cyclodextrin derivative
isothiocyanic acid derivative
solution and solubility
proton nuclear magnetic resonance
scanning electron microscopy
growth, development and aging
microbial sensitivity test
solution and solubility
X ray diffraction
Colony Count, Microbial
Microbial Sensitivity Tests
Proton Magnetic Resonance Spectroscopy
Published Version (Please cite this version)http://dx.doi.org/10.1016/j.colsurfb.2014.04.006
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