Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers
Colloids and Surfaces B: Biointerfaces
125 - 131
Item Usage Stats
MetadataShow full item record
Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. © 2014 Elsevier B.V.
Poly (vinyl alcohol) (PVA)
beta cyclodextrin derivative
isothiocyanic acid derivative
solution and solubility
proton nuclear magnetic resonance
scanning electron microscopy
growth, development and aging
microbial sensitivity test
solution and solubility
X ray diffraction
Colony Count, Microbial
Microbial Sensitivity Tests
Proton Magnetic Resonance Spectroscopy
Published Version (Please cite this version)http://dx.doi.org/10.1016/j.colsurfb.2014.04.006
Showing items related by title, author, creator and subject.
Electrospinning of nanofibers from non-polymeric systems: Polymer-free nanofibers from cyclodextrin derivatives Celebioglu A.; Uyar T. (Royal Society of Chemistry, 2012)High molecular weight polymers and high polymer concentrations are desirable for the electrospinning of nanofibers since polymer chain entanglements and overlapping are important for uniform fiber formation. Hence, the ...
Electrospinning of nanofibers from non-polymeric systems: electrospun nanofibers from native cyclodextrins Celebioglu A.; Uyar T. (Elsevier, 2013)Electrospinning of nanofibers from non-polymeric systems is rather challenging, yet in this study, we have successfully performed electrospinning of nanofibers from two of the native cyclodextrins (CDs); α-CD and β-CD. ...
Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers Canbolat, M. F.; Celebioglu A.; Uyar T. (Elsevier, 2014)In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form ...