Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers
Author
Aytac Z.
Dogan, S.Y.
Tekinay, T.
Uyar, Tamer
Date
2014Source Title
Colloids and Surfaces B: Biointerfaces
Print ISSN
0927-7765
Publisher
Elsevier
Volume
120
Pages
125 - 131
Language
English
Type
ArticleItem Usage Stats
143
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Abstract
Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. © 2014 Elsevier B.V.
Keywords
Allyl isothiocyanateAntibacterial activity
Electrospinning
Nanofibers
Release
β-Cyclodextrin
Bacteria
Cyclodextrins
Electrospinning
Escherichia coli
Allyl isothiocyanate
Anti-bacterial activity
Cyclodextrin complexes
Electrospinning process
Electrospun nanofibers
Inclusion complexation
Poly (vinyl alcohol) (PVA)
Release
Nanofibers
allyl isothiocyanate
beta cyclodextrin
nanofiber
polyvinyl alcohol
allyl isothiocyanate
antiinfective agent
beta cyclodextrin
beta cyclodextrin derivative
isothiocyanic acid derivative
nanofiber
solution and solubility
article
bactericidal activity
bacterium colony
complex formation
concentration (parameters)
controlled study
crystal structure
electrospinning
Escherichia coli
evaporation
mass fragmentography
nanoencapsulation
nonhuman
priority journal
proton nuclear magnetic resonance
scanning electron microscopy
Staphylococcus aureus
tensile strength
bacterial count
chemistry
drug effects
drug release
growth, development and aging
microbial sensitivity test
nanotechnology
procedures
solution and solubility
ultrastructure
X ray diffraction
Anti-Bacterial Agents
beta-Cyclodextrins
Colony Count, Microbial
Drug Liberation
Escherichia coli
Isothiocyanates
Microbial Sensitivity Tests
Nanofibers
Nanotechnology
Proton Magnetic Resonance Spectroscopy
Solutions
Staphylococcus aureus
X-Ray Diffraction
Permalink
http://hdl.handle.net/11693/25569Published Version (Please cite this version)
http://dx.doi.org/10.1016/j.colsurfb.2014.04.006Collections
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