Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers

Files

Release and antibacterial activity of allyl isothiocyanateβ-cyclodextrin complex encapsulated in electrospun nanofibers.pdf (2.01 MB)

Date

2014

Authors

Editor(s)

Advisor

Supervisor

Co-Advisor

Co-Supervisor

Instructor

BUIR Usage Stats
1
views
24
downloads

Citation Stats

  • Share

Series

Abstract

Allyl isothiocyanate (AITC) is known as an efficient antibacterial agent but it has a very high volatility. Herein, AITC and AITC/β-cyclodextrin (CD)-inclusion complex (IC) incorporated in polyvinyl alcohol (PVA) nanofibers were produced via electrospinning. SEM images elucidated that incorporation of AITC and AITC/β-CD-IC into polymer matrix did not affect the bead-free fiber morphology of PVA nanofibers. 1H-NMR and headspace GC-MS analyses revealed that very low amount of AITC was remained in PVA/AITC-NF because of the rapid evaporation of AITC during the electrospinning process. Nevertheless, much higher amount of AITC was preserved in the PVA/AITC/β-CD-IC-NF due to the CD inclusion complexation. The sustained release of AITC from nanofibers was evaluated at 30°C, 50°C and 75°C via headspace GC-MS. When compared to PVA/AITC-NF, PVA/AITC/β-CD-IC-NF has shown higher antibacterial activity against Escherichia coli and Staphylococcus aureus due to the presence of higher amount of AITC in this sample which was preserved by CD-IC. © 2014 Elsevier B.V.

Source Title

Colloids and Surfaces B: Biointerfaces

Publisher

Elsevier

Course

Other identifiers

Book Title

Keywords

Allyl isothiocyanate, Antibacterial activity, Electrospinning, Nanofibers, Release, β-Cyclodextrin, Bacteria, Cyclodextrins, Electrospinning, Escherichia coli, Allyl isothiocyanate, Anti-bacterial activity, Cyclodextrin complexes, Electrospinning process, Electrospun nanofibers, Inclusion complexation, Poly (vinyl alcohol) (PVA), Release, Nanofibers, allyl isothiocyanate, beta cyclodextrin, nanofiber, polyvinyl alcohol, allyl isothiocyanate, antiinfective agent, beta cyclodextrin, beta cyclodextrin derivative, isothiocyanic acid derivative, nanofiber, solution and solubility, article, bactericidal activity, bacterium colony, complex formation, concentration (parameters), controlled study, crystal structure, electrospinning, Escherichia coli, evaporation, mass fragmentography, nanoencapsulation, nonhuman, priority journal, proton nuclear magnetic resonance, scanning electron microscopy, Staphylococcus aureus, tensile strength, bacterial count, chemistry, drug effects, drug release, growth, development and aging, microbial sensitivity test, nanotechnology, procedures, solution and solubility, ultrastructure, X ray diffraction, Anti-Bacterial Agents, beta-Cyclodextrins, Colony Count, Microbial, Drug Liberation, Escherichia coli, Isothiocyanates, Microbial Sensitivity Tests, Nanofibers, Nanotechnology, Proton Magnetic Resonance Spectroscopy, Solutions, Staphylococcus aureus, X-Ray Diffraction

Degree Discipline

Degree Level

Degree Name

Citation

Permalink

http://hdl.handle.net/11693/25569

Published Version (Please cite this version)

http://dx.doi.org/10.1016/j.colsurfb.2014.04.006

Collections

Scholarly Publications - UNAM

Language

English

Type

Article