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      Sterilization of PMMA microfluidic chips by various techniques and investigation of material characteristics

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      Author(s)
      Yavuz, C.
      Oliaei, S. N. B.
      Cetin, B.
      Yesil-Celiktas, O.
      Date
      2016
      Source Title
      Journal of Supercritical Fluids
      Print ISSN
      0896-8446
      Publisher
      Elsevier
      Volume
      107
      Pages
      114 - 121
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      The sterilization of microfluidic chips is a vital step of the fabrication process prior to the customer use in biomedical applications. The aim of this study was to analyze the influence of different sterilization techniques and to compare the characteristics of the material before and after sterilization of polymethylmethacrylate (PMMA) microchips. For this, supercritical carbon dioxide (SC-CO<inf>2</inf>) along with standard sterilization methods such as ultraviolet (UV), heat (autoclaving), ethylene oxide (EtO) and hydrogen peroxide (H<inf>2</inf>O<inf>2</inf>) were applied. The treated microchips were analyzed by Scanning Electron Microscopy, Differential Scanning Calorimetry, Fourier Transform Infrared Spectroscopy and Laser Scanning Microscopy in order to ascertain any changes in the chemical structure and surface morphology. The optimum sterilization parameters for SC-CO<inf>2</inf> were elicited as 120 bar, 40°C and 60 min which provided complete sterility and did not alter the main properties of the polymer along with EtO and H<inf>2</inf>O<inf>2</inf> sterilizations unlike heat and UV treatments. However, surface roughness and microchannel profiles were negatively affected. Although complete sterility was achieved, each protocol has its own strengths and weaknesses. © 2015 Elsevier B.V. All rights reserved.
      Keywords
      Material
      Microchip
      Microfluidic device
      PMMA
      Sterilization
      Supercritical CO<inf>2</inf>
      Carbon
      Carbon dioxide
      Chemical analysis
      Differential scanning calorimetry
      Ethylene
      Fluidic devices
      Fourier transform infrared spectroscopy
      Materials
      Medical applications
      Permalink
      http://hdl.handle.net/11693/24591
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.supflu.2015.08.019
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