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      • Faculty of Engineering
      • Department of Electrical and Electronics Engineering
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      In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction

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      Author(s)
      Kraitchman, D. L.
      Heldman, A. W.
      Atalar, Ergin
      Amado, L. C.
      Martin, B. J.
      Pittenger, M. F.
      Hare, J. M.
      Bulte, J. W. M.
      Date
      2003
      Source Title
      Circulation
      Print ISSN
      0009-7322
      Publisher
      Lippincott Williams & Wilkins
      Volume
      107
      Issue
      18
      Pages
      2290 - 2293
      Language
      English
      Type
      Article
      Item Usage Stats
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      214
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      Abstract
      Background - We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results - Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion - MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.
      Keywords
      Cells
      Contrast media
      Magnetic resonance imaging
      Myocardial infarction
      Animal cell
      Animal experiment
      Animal model
      Contrast enhancement
      Device
      Feasibility study
      Fluoroscopy
      Heart infarction
      Mesenchyme
      Nonhuman
      Nuclear magnetic resonance imaging
      Priority journal
      Stem cell
      Swine
      Technique
      Animals
      Injections
      Iron
      Myocardium
      Stem Cell Transplantation
      Stem Cells
      Swine
      Permalink
      http://hdl.handle.net/11693/24482
      Published Version (Please cite this version)
      http://dx.doi.org/10.1161/01.CIR.0000070931.62772.4E
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