In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
Author(s)
Date
2003Source Title
Circulation
Print ISSN
0009-7322
Publisher
Lippincott Williams & Wilkins
Volume
107
Issue
18
Pages
2290 - 2293
Language
English
Type
ArticleItem Usage Stats
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Abstract
Background - We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results - Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion - MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.
Keywords
CellsContrast media
Magnetic resonance imaging
Myocardial infarction
Animal cell
Animal experiment
Animal model
Contrast enhancement
Device
Feasibility study
Fluoroscopy
Heart infarction
Mesenchyme
Nonhuman
Nuclear magnetic resonance imaging
Priority journal
Stem cell
Swine
Technique
Animals
Injections
Iron
Myocardium
Stem Cell Transplantation
Stem Cells
Swine