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dc.contributor.authorCakan, G.en_US
dc.contributor.authorTurkoz, M.en_US
dc.contributor.authorTuran, T.en_US
dc.contributor.authorAhmed, K.en_US
dc.contributor.authorNagatake, T.en_US
dc.date.accessioned2016-02-08T10:29:56Z
dc.date.available2016-02-08T10:29:56Z
dc.date.issued2003en_US
dc.identifier.issn0882-4010
dc.identifier.urihttp://hdl.handle.net/11693/24474
dc.description.abstractStreptococcus pneumoniae causes respiratory and other invasive infections. Increased resistance of this bacterium to antibiotics necessitates new approaches to the treatment of infections. Attachment of bacteria to human pharyngeal epithelial cells is the initial step in the pathogenesis of infection and S-carboxymethylcysteine (S-CMC) can modulate the attachment of Moraxella catarrhalis and nontypable Haemophilus influenzae to epithelial cells. Unlike these two, S. pneumoniae is gram-positive and has a well-defined capsule. Here we examined the effects of S-CMC on the attachment and detachment of S. pneumoniae to human pharyngeal epithelial cells in vitro. Treatment of these cells with S-CMC significantly reduced the number of attached S. pneumoniae. S-CMC also resulted in a significant increase in the detachment of already attached S. pneumoniae to epithelial cells. In addition, treatment of S. pneumoniae with S-CMC significantly reduced their ability to attach to epithelial cells, but not the number of viable bacteria. Our study shows that S-CMC modulates the attachment of S. pneumoniae to human pharyngeal epithelial cells by acting both on cells and bacteria. © 2003 Elsevier Science Ltd. All rights reserved.en_US
dc.language.isoEnglishen_US
dc.source.titleMicrobial Pathogenesisen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/S0882-4010(03)00048-2en_US
dc.subjectBacterial adherenceen_US
dc.subjectBacterial attachmenten_US
dc.subjectEpithelial cellsen_US
dc.subjectMucosaen_US
dc.subjectRespiratory infectionen_US
dc.subjectCcarbocisteineen_US
dc.subjectAntimicrobial activityen_US
dc.titleS-carboxymethylcysteine inhibits the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cellsen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage261en_US
dc.citation.epage265en_US
dc.citation.volumeNumber34en_US
dc.citation.issueNumber6en_US
dc.identifier.doi10.1016/S0882-4010(03)00048-2en_US
dc.publisherElsevieren_US


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