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dc.contributor.authorUzunalli, Gözdeen_US
dc.contributor.authorTumtas, Yasinen_US
dc.contributor.authorDelibasi, T.en_US
dc.contributor.authorYasa, Oncayen_US
dc.contributor.authorMercan, S.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.authorTekinay, Ayse B.en_US
dc.date.accessioned2016-02-08T10:29:03Z
dc.date.available2016-02-08T10:29:03Z
dc.date.issued2015en_US
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/11693/24414
dc.description.abstractPancreatic islet transplantation is a promising treatment for type 1 diabetes. However, viability and functionality of the islets after transplantation are limited due to loss of integrity and destruction of blood vessel networks. Thus, it is important to provide a proper mechanically and biologically supportive environment for enhancing both in vitro islet culture and transplantation efficiency. Here, we demonstrate that heparin mimetic peptide amphiphile (HM-PA) nanofibrous network is a promising platform for these purposes. The islets cultured with peptide nanofiber gel containing growth factors exhibited a similar glucose stimulation index as that of the freshly isolated islets even after 7 days. After transplantation of islets to STZ-induced diabetic rats, 28 day-long monitoring displayed that islets that were transplanted in HM-PA nanofiber gels maintained better blood glucose levels at normal levels compared to the only islet transplantation group. In addition, intraperitoneal glucose tolerance test revealed that animals that were transplanted with islets within peptide gels showed a similar pattern with the healthy control group. Histological assessment showed that islets transplanted within peptide nanofiber gels demonstrated better islet integrity due to increased blood vessel density. This work demonstrates that using the HM-PA nanofiber gel platform enhances the islets function and islet transplantation efficiency both in vitro and in vivo.en_US
dc.language.isoEnglishen_US
dc.source.titleActa Biomaterialiaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.actbio.2015.04.032en_US
dc.subjectHeparinen_US
dc.subjectPeptide nanofibersen_US
dc.subjectSelf-assemblyen_US
dc.subjectIslet transplantationen_US
dc.subjectAngiogenesisen_US
dc.titleImproving pancreatic islet in vitro functionality and transplantation efficiency by using heparin mimetic peptide nanofiber gelsen_US
dc.typeArticleen_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.citation.spage8en_US
dc.citation.epage18en_US
dc.citation.volumeNumber22en_US
dc.identifier.doi10.1016/j.actbio.2015.04.032en_US
dc.publisherElsevieren_US
dc.contributor.bilkentauthorUzunalli, Gözdeen_US
dc.contributor.bilkentauthorTumtas, Yasinen_US
dc.contributor.bilkentauthorYasa, Oncayen_US
dc.contributor.bilkentauthorGüler, Mustafa O.en_US
dc.contributor.bilkentauthorTekinay, Ayse B.en_US


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