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dc.contributor.authorKarmarkar, P. V.en_US
dc.contributor.authorKraitchman, D. L.en_US
dc.contributor.authorIzbudak, I.en_US
dc.contributor.authorHofmann, L. V.en_US
dc.contributor.authorAmado, L. C.en_US
dc.contributor.authorFritzges, D.en_US
dc.contributor.authorYoung, R.en_US
dc.contributor.authorPittenger, M.en_US
dc.contributor.authorBulte, J. W. M.en_US
dc.contributor.authorAtalar, Erginen_US
dc.date.accessioned2016-02-08T10:26:49Z
dc.date.available2016-02-08T10:26:49Z
dc.date.issued2004en_US
dc.identifier.issn0740-3194
dc.identifier.urihttp://hdl.handle.net/11693/24276
dc.description.abstractThere is growing interest in delivering cellular agents to infarcted myocardium to prevent postinfarction left ventricular remodeling. MRI can be effectively used to differentiate infarcted from healthy myocardium. MR-guided delivery of cellular agents/therapeutics is appealing because the therapeutics can be precisely targeted to the desired location within the infarct. In this study, a steerable intramyocardial injection catheter that can be actively tracked under MRI was developed and tested. The components of the catheter were arranged to form a loopless RF antenna receiver coil that enabled active tracking. Feasibility studies were performed in canine and porcine myocardial infarction models. Myocardial delayed-enhancement (MDE) imaging identified the infarcted myocardium, and real-time MRI was used to guide left ventricular catheterization from a carotid artery approach. The distal 35 cm of the catheter was seen under MRI with a bright signal at the distal tip of the catheter. The catheter was steered into position, the distal tip was apposed against the infarct, the needle was advanced, and a bolus of MR contrast agent and tissue marker dye was injected intramyocardially, as confirmed by imaging and post-mortem histology. A pilot study involving intramyocardial delivery of magnetically labeled stem cells demonstrated the utility of the active injection catheter system.en_US
dc.language.isoEnglishen_US
dc.source.titleMagnetic Resonance in Medicineen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/mrm.20086en_US
dc.subjectCardiac MRIen_US
dc.subjectCatheter trackingen_US
dc.subjectInterventional MRIen_US
dc.subjectIntramyocardial injection catheteren_US
dc.subjectIntramyocardial injectionsen_US
dc.subjectIron oxide MR contrast agenten_US
dc.subjectLabeled stem cellsen_US
dc.subjectBiochemical markeren_US
dc.subjectContrast mediumen_US
dc.subjectIron oxideen_US
dc.subjectAdoptive immunotherapyen_US
dc.titleMR-trackable intramyocardial injection catheteren_US
dc.typeArticleen_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.citation.spage1163en_US
dc.citation.epage1172en_US
dc.citation.volumeNumber51en_US
dc.citation.issueNumber6en_US
dc.identifier.doi10.1002/mrm.20086en_US
dc.publisherJohn Wiley & Sonsen_US
dc.contributor.bilkentauthorAtalar, Ergin
dc.identifier.eissn1522-2594


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