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dc.contributor.authorSevinç, A.en_US
dc.contributor.authorYannoukakos, D.en_US
dc.contributor.authorKonstantopoulou, I.en_US
dc.contributor.authorManguoglu, E.en_US
dc.contributor.authorLüleci, G.en_US
dc.contributor.authorÇolak, T.en_US
dc.contributor.authorAkyerli, C.en_US
dc.contributor.authorÇolakoglu, G.en_US
dc.contributor.authorTez, M.en_US
dc.contributor.authorSayek, I.en_US
dc.contributor.authorGerassimos, V.en_US
dc.contributor.authorNasioulas, G.en_US
dc.contributor.authorPapadopoulou, E.en_US
dc.contributor.authorFlorentin, L.en_US
dc.contributor.authorKontogianni, E.en_US
dc.contributor.authorBozkurt, B.en_US
dc.contributor.authorKocabas, N. A.en_US
dc.contributor.authorKarakaya, A. E.en_US
dc.contributor.authorYulug, I. G.en_US
dc.contributor.authorÖzçelik, T.en_US
dc.date.accessioned2016-02-08T10:26:37Z
dc.date.available2016-02-08T10:26:37Z
dc.date.issued2004en_US
dc.identifier.issn0250-7005
dc.identifier.urihttp://hdl.handle.net/11693/24266
dc.description.abstractBackground: The RNASEL G1385A variant was recently found to be implicated in the development of prostate cancer. Considering the function of RNase L and the pleiotropic effects of mutations associated with cancer, we sought to investigate whether the RNASEL G1385A variant is a risk factor for breast cancer. Patients and Methods: A total of 453 breast cancer patients and 382 age- and sex-matched controls from Greece and Turkey were analyzed. Genotyping for the RNASEL G1385A variant was performed using an Amplification Refractory Mutation System (ARMS). Results: Statistical evaluation of the RNASEL G1385A genotype distribution among breast cancer patients and controls revealed no significant association between the presence of the risk genotype and the occurrence of breast cancer. Conclusion: Although an increasing number of studies report an association between the RNASEL G1385A variant and prostate cancer risk, this variant does not appear to be implicated in the development of breast cancer.en_US
dc.language.isoEnglishen_US
dc.source.titleAnticancer Researchen_US
dc.subjectBreast canceren_US
dc.subjectRNASELen_US
dc.subjectArginineen_US
dc.subjectGlutamineen_US
dc.subjectRibonuclease Len_US
dc.subjectAdolescenten_US
dc.subjectAgeden_US
dc.subjectAmino acid sequenceen_US
dc.subjectAmplification refractory mutation systemen_US
dc.subjectArticleen_US
dc.subjectBreast canceren_US
dc.subjectCancer risken_US
dc.subjectControlled studyen_US
dc.subjectDisease associationen_US
dc.subjectFemaleen_US
dc.subjectGene amplificationen_US
dc.subjectGene mutationen_US
dc.subjectGenotypeen_US
dc.subjectGreeceen_US
dc.subjectHumanen_US
dc.subjectHuman tissueen_US
dc.subjectMajor clinical studyen_US
dc.subjectPleiotropyen_US
dc.subjectPriority journalen_US
dc.subjectProtein varianten_US
dc.subjectRisk factoren_US
dc.subjectTurkey (republic)en_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectAllelesen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectCase-Control Studiesen_US
dc.subjectDNA, Neoplasmen_US
dc.subjectEndoribonucleasesen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMiddle ageden_US
dc.subjectMutationen_US
dc.subjectRisk factorsen_US
dc.titleLack of association between RNASEL Arg462Gln variant and the risk of breast canceren_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Genetics
dc.citation.spage2547en_US
dc.citation.epage2549en_US
dc.citation.volumeNumber24en_US
dc.citation.issueNumber4en_US
dc.publisherInternational Institute of Anticancer Researchen_US


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