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      Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer

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      Author
      Sevinç, A.
      Yannoukakos, D.
      Konstantopoulou, I.
      Manguoglu, E.
      Lüleci, G.
      Çolak, T.
      Akyerli, C.
      Çolakoglu, G.
      Tez, M.
      Sayek, I.
      Gerassimos, V.
      Nasioulas, G.
      Papadopoulou, E.
      Florentin, L.
      Kontogianni, E.
      Bozkurt, B.
      Kocabas, N. A.
      Karakaya, A. E.
      Yulug, I. G.
      Özçelik, T.
      Date
      2004
      Source Title
      Anticancer Research
      Print ISSN
      0250-7005
      Publisher
      International Institute of Anticancer Research
      Volume
      24
      Issue
      4
      Pages
      2547 - 2549
      Language
      English
      Type
      Article
      Item Usage Stats
      78
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      16
      downloads
      Abstract
      Background: The RNASEL G1385A variant was recently found to be implicated in the development of prostate cancer. Considering the function of RNase L and the pleiotropic effects of mutations associated with cancer, we sought to investigate whether the RNASEL G1385A variant is a risk factor for breast cancer. Patients and Methods: A total of 453 breast cancer patients and 382 age- and sex-matched controls from Greece and Turkey were analyzed. Genotyping for the RNASEL G1385A variant was performed using an Amplification Refractory Mutation System (ARMS). Results: Statistical evaluation of the RNASEL G1385A genotype distribution among breast cancer patients and controls revealed no significant association between the presence of the risk genotype and the occurrence of breast cancer. Conclusion: Although an increasing number of studies report an association between the RNASEL G1385A variant and prostate cancer risk, this variant does not appear to be implicated in the development of breast cancer.
      Keywords
      Breast cancer
      RNASEL
      Arginine
      Glutamine
      Ribonuclease L
      Adolescent
      Aged
      Amino acid sequence
      Amplification refractory mutation system
      Article
      Breast cancer
      Cancer risk
      Controlled study
      Disease association
      Female
      Gene amplification
      Gene mutation
      Genotype
      Greece
      Human
      Human tissue
      Major clinical study
      Pleiotropy
      Priority journal
      Protein variant
      Risk factor
      Turkey (republic)
      Adult
      Aged
      Aged, 80 and over
      Alleles
      Breast Neoplasms
      Case-Control Studies
      DNA, Neoplasm
      Endoribonucleases
      Female
      Humans
      Middle aged
      Mutation
      Risk factors
      Permalink
      http://hdl.handle.net/11693/24266
      Collections
      • Department of Molecular Biology and Genetics 426
      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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