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dc.contributor.authorAtagün, M. İ.en_US
dc.contributor.authorŞıkoğlu, E. M.en_US
dc.contributor.authorCan, S. S.en_US
dc.contributor.authorKarakaş-Uğurlu, G.en_US
dc.contributor.authorUlusoy-Kaymak, S.en_US
dc.contributor.authorÇayköylü, A.en_US
dc.contributor.authorAlgın, O.en_US
dc.contributor.authorPhillips, M. L.en_US
dc.contributor.authorMoore, C. M.en_US
dc.contributor.authorÖngür, D.en_US
dc.date.accessioned2016-02-08T10:25:37Z
dc.date.available2016-02-08T10:25:37Z
dc.date.issued2015en_US
dc.identifier.issn0920-9964
dc.identifier.urihttp://hdl.handle.net/11693/24203
dc.description.abstractBackground: Superior temporal cortices include brain regions dedicated to auditory processing and several lines of evidence suggest structural and functional abnormalities in both schizophrenia and bipolar disorder within this brain region. However, possible glutamatergic dysfunction within this region has not been investigated in adult patients. Methods: Thirty patients with schizophrenia (38.67 ± 12.46. years of age), 28 euthymic patients with bipolar I disorder (35.32 ± 9.12. years of age), and 30 age-, gender- and education-matched healthy controls were enrolled. Proton magnetic resonance spectroscopy data were acquired using a 3.0. T Siemens MAGNETOM TIM Trio MR system and single voxel Point REsolved Spectroscopy Sequence (PRESS) in order to quantify brain metabolites within the left and right Heschl's gyrus and planum temporale of superior temporal cortices. Results: There were significant abnormalities in glutamate (Glu) (F(2,78) = 8.52, p < 0.0001), N-acetyl aspartate (tNAA) (F(2,81) = 5.73, p = 0.005), creatine (tCr) (F(2,83) = 5.91, p = 0.004) and inositol (Ins) (F(2,82) = 8.49, p < 0.0001) concentrations in the left superior temporal cortex. In general, metabolite levels were lower for bipolar disorder patients when compared to healthy participants. Moreover, patients with bipolar disorder exhibited significantly lower tCr and Ins concentrations when compared to schizophrenia patients. In addition, we have found significant correlations between the superior temporal cortex metabolites and clinical measures. Conclusion: As the left auditory cortices are associated with language and speech, left hemisphere specific abnormalities may have clinical significance. Our findings are suggestive of shared glutamatergic abnormalities in schizophrenia and bipolar disorder. © 2013 Elsevier B.V.en_US
dc.language.isoEnglishen_US
dc.source.titleSchizophrenia Researchen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.schres.2014.11.012en_US
dc.subjectBipolar disorderen_US
dc.subjectGlutamateen_US
dc.subjectGlutamineen_US
dc.subjectMagnetic resonance spectroscopyen_US
dc.subjectSchizophreniaen_US
dc.subjectSuperior temporal cortexen_US
dc.titleInvestigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: a proton magnetic resonance spectroscopy studyen_US
dc.typeArticleen_US
dc.departmentNational Magnetic Resonance Research Center - UMRAMen_US
dc.citation.spage202en_US
dc.citation.epage209en_US
dc.citation.volumeNumber161en_US
dc.citation.issueNumber2-3en_US
dc.identifier.doi10.1016/j.schres.2014.11.012en_US
dc.publisherElsevieren_US


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