Expression of IFITM1 in chronic myeloid leukemia patients
Akyerli, C. B.
Williams, B. R. G.
283 - 286
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We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 × 10-11) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.
KeywordsChronic myeloid leukemia
Interferon induced transmembrane protein 1
Chronic myeloid leukemia
High risk population
Major clinical study
Real time polymerase chain reaction
Leukemia, Myeloid, Chronic
Reverse Transcriptase Polymerase Chain Reaction
Tumor Markers, Biological