Expression of IFITM1 in chronic myeloid leukemia patients
Author(s)
Date
2005Source Title
Leukemia Research
Print ISSN
0145-2126
Publisher
Elsevier
Volume
29
Issue
3
Pages
283 - 286
Language
English
Type
ArticleItem Usage Stats
281
views
views
273
downloads
downloads
Abstract
We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 × 10-11) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.
Keywords
Chronic myeloid leukemiaGene expression
IFITM1
RT-PCR
Interferon induced transmembrane protein 1
Membrane protein
Unclassified drug
Article
Blood
Cell adhesion
Cell proliferation
Chronic myeloid leukemia
Controlled study
Correlation analysis
Disease classification
Female
Gene expression
High risk population
Human
Major clinical study
Male
Prediction
Priority journal
Prognosis
Real time polymerase chain reaction
Signal transduction
Survival
Adult
Aged
Humans
Leukemia, Myeloid, Chronic
Male
Membrane Proteins
Middle Aged
Prognosis
Reverse Transcriptase Polymerase Chain Reaction
Survival Analysis
Tumor Markers, Biological