• About
  • Policies
  • What is open access
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Molecular Biology and Genetics
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Molecular Biology and Genetics
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Expression of IFITM1 in chronic myeloid leukemia patients

      Thumbnail
      View / Download
      76.5 Kb
      Author(s)
      Akyerli, C. B.
      Beksac, M.
      Holko, M.
      Frevel, M.
      Dalva, K.
      Özbek, U.
      Soydan, E.
      Özcan, M.
      Özet, G.
      İlhan, O.
      Gürman, G.
      Akan, H.
      Williams, B. R. G.
      Özçelik, T.
      Date
      2005
      Source Title
      Leukemia Research
      Print ISSN
      0145-2126
      Publisher
      Elsevier
      Volume
      29
      Issue
      3
      Pages
      283 - 286
      Language
      English
      Type
      Article
      Item Usage Stats
      281
      views
      273
      downloads
      Abstract
      We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 × 10-11) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.
      Keywords
      Chronic myeloid leukemia
      Gene expression
      IFITM1
      RT-PCR
      Interferon induced transmembrane protein 1
      Membrane protein
      Unclassified drug
      Article
      Blood
      Cell adhesion
      Cell proliferation
      Chronic myeloid leukemia
      Controlled study
      Correlation analysis
      Disease classification
      Female
      Gene expression
      High risk population
      Human
      Major clinical study
      Male
      Prediction
      Priority journal
      Prognosis
      Real time polymerase chain reaction
      Signal transduction
      Survival
      Adult
      Aged
      Humans
      Leukemia, Myeloid, Chronic
      Male
      Membrane Proteins
      Middle Aged
      Prognosis
      Reverse Transcriptase Polymerase Chain Reaction
      Survival Analysis
      Tumor Markers, Biological
      Permalink
      http://hdl.handle.net/11693/24093
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.leukres.2004.07.007
      Collections
      • Department of Molecular Biology and Genetics 542
      • Institute of Materials Science and Nanotechnology (UNAM) 2258
      Show full item record

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsCoursesThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsCourses

      My Account

      Login

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 2976
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy