Expression of IFITM1 in chronic myeloid leukemia patients
Date
2005
Authors
Akyerli, C. B.
Beksac, M.
Holko, M.
Frevel, M.
Dalva, K.
Özbek, U.
Soydan, E.
Özcan, M.
Özet, G.
İlhan, O.
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Abstract
We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 × 10-11) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.
Source Title
Leukemia Research
Publisher
Elsevier
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Keywords
Chronic myeloid leukemia, Gene expression, IFITM1, RT-PCR, Interferon induced transmembrane protein 1, Membrane protein, Unclassified drug, Article, Blood, Cell adhesion, Cell proliferation, Chronic myeloid leukemia, Controlled study, Correlation analysis, Disease classification, Female, Gene expression, High risk population, Human, Major clinical study, Male, Prediction, Priority journal, Prognosis, Real time polymerase chain reaction, Signal transduction, Survival, Adult, Aged, Humans, Leukemia, Myeloid, Chronic, Male, Membrane Proteins, Middle Aged, Prognosis, Reverse Transcriptase Polymerase Chain Reaction, Survival Analysis, Tumor Markers, Biological
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Language
English