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dc.contributor.authorGuran, Ş.en_US
dc.contributor.authorBeyan, C.en_US
dc.contributor.authorNevruz, O.en_US
dc.contributor.authorYakıcıer, C.en_US
dc.contributor.authorTunca, Y.en_US
dc.date.accessioned2016-02-08T10:23:50Z
dc.date.available2016-02-08T10:23:50Z
dc.date.issued2005en_US
dc.identifier.issn0141-9854
dc.identifier.urihttp://hdl.handle.net/11693/24082
dc.description.abstractLi-Fraumeni syndrome is a familial cancer syndrome characterized by different tumors and hereditary p53 mutations. Here, a chronic myeloid leukemia-like syndrome case in a Li-Fraumeni syndrome family with del (12) (p12) cytogenetic abnormality was presented. A hereditary p53 mutation (pro309ser) supported the Li-Fraumeni syndrome diagnosis in this family. This syndrome was characterized by the clonal myeloproliferative accumulation in bone marrow and peripheral blood with negative bcr/abl gene rearrangement finding. The etiology of this rare syndrome is still unclear. This is the only chronic myeloid leukemia-like syndrome case reported in a Li-Fraumeni syndrome family. Del (12) (p12) was observed in leukemias except chronic myeloid leukemia-like syndrome. The deletion in chromosome 12pl2 with hereditary p53 mutation should have a critical role in chronic myeloid leukemia-like syndrome etiology in our case. © 2005 Blackwell Publishing Ltd.en_US
dc.language.isoEnglishen_US
dc.source.titleClinical and Laboratory Haematologyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1111/j.1365-2257.2005.00679.xen_US
dc.subjectbcr/abl translocationen_US
dc.subjectChronic myeloiden_US
dc.subjectLeukemia-like syndromeen_US
dc.subjectLi-Fraumeni syndromeen_US
dc.subjectp53en_US
dc.subjectPhiladelphia chromosomeen_US
dc.subjectDNAen_US
dc.subjectProtein p53en_US
dc.subjectRNAen_US
dc.titleA chronic myeloid leukemia-like syndrome case with del (12) (p12) in a Li-Fraumeni syndrome familyen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage135en_US
dc.citation.epage138en_US
dc.citation.volumeNumber27en_US
dc.citation.issueNumber2en_US
dc.identifier.doi10.1111/j.1365-2257.2005.00679.xen_US
dc.publisherBlackwell Publishing Ltden_US


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