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      Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant

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      Author(s)
      Çorapçıoğlu, F.
      Özek, M. M.
      Sav, A.
      Üren, Deniz
      Date
      2006
      Source Title
      Child's Nervous System
      Print ISSN
      0256-7040
      Publisher
      Springer
      Volume
      22
      Issue
      5
      Pages
      533 - 538
      Language
      English
      Type
      Article
      Item Usage Stats
      375
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      363
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      Abstract
      Background: Pineoblastomas are very rare brain tumors in fetus and neonates, comprising only 0.9% of congenital brain tumors. The occurrence of multiple tumors of different histopathologic types in the same individual is a rare event, most often encountered in hereditary cancer syndromes. Case Report: We report a female fetus presented with a congenital pineoblastoma at the 32nd week of gestation, with hydrocephalus and concurrent parameningeal embryonal rhabdomyosarcoma in early infancy. Results: Cytogenetic analysis showed normal karyotype in the peripheral blood of the patient, and p53 mutational analysis revealed no germ line mutations. Discussion: This is the first case with concurrent congenital pineoblastoma and parameningeal embryonal rhabdomyosarcoma in early infancy. We suggest that concurrence of these tumors could be due to mutations in other tumor suppressor genes or secondary to exposure to unknown in utero factors.
      Keywords
      Brain tumor
      Congenital
      p53 gene mutation
      Pineoblastoma
      Rhabdomyosarcoma
      Permalink
      http://hdl.handle.net/11693/23811
      Published Version (Please cite this version)
      https://doi.org/10.1007/s00381-005-0006-2
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      • Genetics and Biotechnology Research Center (BİLGEN) 16
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