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      MDM2 T309G polymorphism is associated with bladder cancer

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      Author
      Onat, O. E.
      Tez, M.
      Özçelik, T.
      Törüner, G. A.
      Date
      2006
      Source Title
      Anticancer Research
      Print ISSN
      0250-7005
      Publisher
      International Institute of Anticancer Research
      Volume
      26
      Issue
      5 A
      Pages
      3473 - 3475
      Language
      English
      Type
      Article
      Item Usage Stats
      119
      views
      26
      downloads
      Abstract
      Recently, a functional T to G polymorphism at nucleotide 309 in the promoter region of the MDM2 gene (rs: 2279744, SNP 309) has been identified. This polymorphism has an impact on the expression of the MDM2 gene, which is a key negative regulator of the tumor suppressor molecule p53. The effect of T309G polymorphism of the MDM2 gene on bladder cancer susceptibility was investigated in a case-control study of 75 bladder cancer patients and 103 controls from Turkey. The G/G genotype exhibited an increased risk of 2.68 (95% CI, 1.34-5.40) for bladder cancer compared with the combination of low-risk genotypes T/T and T/G at this locus. These results show an association between MDM2 T309G polymorphism and bladder cancer in our study group. To the best of our knowledge, this is the first study reporting that MDM2 T309G polymorphism may be a potential genetic susceptibility factor for bladder cancer.
      Keywords
      Bladder cancer
      Cancer predisposition
      Case-control study
      MDM2 polymorphism
      Adult
      Aged
      Article
      Bladder cancer
      Cancer risk
      Case control study
      Confidence interval
      Controlled study
      Disease association
      Gene expression
      Genetic polymorphism
      Genetic susceptibility
      Genotype
      Human
      Major clinical study
      Priority journal
      Promoter region
      Topography
      Turkey (republic)
      Adult
      Aged
      Aged, 80 and over
      Case-Control studies
      DNA Mutational analysis
      Female
      Genotype
      Humans
      Male
      Middle aged
      Odds ratio
      Polymorphism, Single nucleotide
      Promoter regions (Genetics)
      Proto-Oncogene Proteins c-mdm2
      Risk factors
      Urinary bladder neoplasms
      Permalink
      http://hdl.handle.net/11693/23727
      Collections
      • Department of Molecular Biology and Genetics 460
      • Institute of Materials Science and Nanotechnology (UNAM) 1891
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