MDM2 T309G polymorphism is associated with bladder cancer
Author
Onat, O. E.
Tez, M.
Özçelik, T.
Törüner, G. A.
Date
2006Source Title
Anticancer Research
Print ISSN
0250-7005
Publisher
International Institute of Anticancer Research
Volume
26
Issue
5 A
Pages
3473 - 3475
Language
English
Type
ArticleItem Usage Stats
119
views
views
26
downloads
downloads
Abstract
Recently, a functional T to G polymorphism at nucleotide 309 in the promoter region of the MDM2 gene (rs: 2279744, SNP 309) has been identified. This polymorphism has an impact on the expression of the MDM2 gene, which is a key negative regulator of the tumor suppressor molecule p53. The effect of T309G polymorphism of the MDM2 gene on bladder cancer susceptibility was investigated in a case-control study of 75 bladder cancer patients and 103 controls from Turkey. The G/G genotype exhibited an increased risk of 2.68 (95% CI, 1.34-5.40) for bladder cancer compared with the combination of low-risk genotypes T/T and T/G at this locus. These results show an association between MDM2 T309G polymorphism and bladder cancer in our study group. To the best of our knowledge, this is the first study reporting that MDM2 T309G polymorphism may be a potential genetic susceptibility factor for bladder cancer.
Keywords
Bladder cancerCancer predisposition
Case-control study
MDM2 polymorphism
Adult
Aged
Article
Bladder cancer
Cancer risk
Case control study
Confidence interval
Controlled study
Disease association
Gene expression
Genetic polymorphism
Genetic susceptibility
Genotype
Human
Major clinical study
Priority journal
Promoter region
Topography
Turkey (republic)
Adult
Aged
Aged, 80 and over
Case-Control studies
DNA Mutational analysis
Female
Genotype
Humans
Male
Middle aged
Odds ratio
Polymorphism, Single nucleotide
Promoter regions (Genetics)
Proto-Oncogene Proteins c-mdm2
Risk factors
Urinary bladder neoplasms
Permalink
http://hdl.handle.net/11693/23727Collections
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