DNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish population
Date
2006Source Title
Anticancer Research
Print ISSN
0250-7005
Publisher
International Institute of Anticancer Research
Volume
26
Issue
6 C
Pages
4955 - 4958
Language
English
Type
ArticleItem Usage Stats
198
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views
250
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downloads
Abstract
Background: Occupational exposure and life style preferences, such as smoking are the main known environmental susceptibility factors for bladder cancer. A growing list of chemicals has been shown to induce oxidative DNA damage. Base excision repair (BER) genes (X-ray repair cross complementing 1, XRCC1 and human 8-oxoguanine DNA glycosylase 1, OGG1) may play a key role in maintaining genome integrity and preventing cancer development. Materials and Methods: We tested whether polymorphisms in XRCC1 and OGG1 are associated with bladder cancer risk by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) assay. In addition, the possible modifying affect of cigarette smoking was evaluated. Results: No studies, to date, have examined the association between genetic polymorphisms in DNA repair genes and bladder cancer susceptibility, in the Turkish population. We found the OGG1 Cys326Cys genotype to be more frequent among bladder cancer patients (odds ratio (OR): 2.41 (95% CI, 1.36-4.25)). However, in the case of XRCC1, there was no significant difference in susceptibility to bladder cancer development between patients with the Arg399 and these with the Gln399 allele (OR: 0.72 (95% CI, 0.41-1.26)). Conclusion: Our data showed that OGG1 genetic polymorphisms might be useful as prognostic genetic markers for bladder cancer in the clinical setting.
Keywords
Arg399GlnBladder cancer
Cigarette smoking
OGG
Polymorphism
Ser326Cys
Turkish population
XRCC1
Arginine
Cysteine
Glutamine
Nuclear protein
Protein 8 oxoguanine dna glycosylase 1
Protein x ray repair cross complementing 1
Unclassified drug
Adult
Aged
Article
Bladder cancer
Cancer risk
Cancer susceptibility
Cigarette smoking
Controlled study
DNA polymorphism
DNA repair
Excision repair
Gene frequency
Genetic analysis
Human
Major clinical study
Polymerase chain reaction
Priority journal
Restriction fragment length polymorphism
Turkey (republic)
Adult
Aged
Aged, 80 and over
DNA Glycosylases
DNA Repair
DNA-Binding Proteins
Genetic predisposition to disease
Humans
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction fragment length
Turkey
Urinary bladder neoplasms
Permalink
http://hdl.handle.net/11693/23684Collections
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