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      DNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish population

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      Author(s)
      Karahalil, B.
      Kocabas, N. A.
      Özçelik, T.
      Date
      2006
      Source Title
      Anticancer Research
      Print ISSN
      0250-7005
      Publisher
      International Institute of Anticancer Research
      Volume
      26
      Issue
      6 C
      Pages
      4955 - 4958
      Language
      English
      Type
      Article
      Item Usage Stats
      168
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      226
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      Abstract
      Background: Occupational exposure and life style preferences, such as smoking are the main known environmental susceptibility factors for bladder cancer. A growing list of chemicals has been shown to induce oxidative DNA damage. Base excision repair (BER) genes (X-ray repair cross complementing 1, XRCC1 and human 8-oxoguanine DNA glycosylase 1, OGG1) may play a key role in maintaining genome integrity and preventing cancer development. Materials and Methods: We tested whether polymorphisms in XRCC1 and OGG1 are associated with bladder cancer risk by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) assay. In addition, the possible modifying affect of cigarette smoking was evaluated. Results: No studies, to date, have examined the association between genetic polymorphisms in DNA repair genes and bladder cancer susceptibility, in the Turkish population. We found the OGG1 Cys326Cys genotype to be more frequent among bladder cancer patients (odds ratio (OR): 2.41 (95% CI, 1.36-4.25)). However, in the case of XRCC1, there was no significant difference in susceptibility to bladder cancer development between patients with the Arg399 and these with the Gln399 allele (OR: 0.72 (95% CI, 0.41-1.26)). Conclusion: Our data showed that OGG1 genetic polymorphisms might be useful as prognostic genetic markers for bladder cancer in the clinical setting.
      Keywords
      Arg399Gln
      Bladder cancer
      Cigarette smoking
      OGG
      Polymorphism
      Ser326Cys
      Turkish population
      XRCC1
      Arginine
      Cysteine
      Glutamine
      Nuclear protein
      Protein 8 oxoguanine dna glycosylase 1
      Protein x ray repair cross complementing 1
      Unclassified drug
      Adult
      Aged
      Article
      Bladder cancer
      Cancer risk
      Cancer susceptibility
      Cigarette smoking
      Controlled study
      DNA polymorphism
      DNA repair
      Excision repair
      Gene frequency
      Genetic analysis
      Human
      Major clinical study
      Polymerase chain reaction
      Priority journal
      Restriction fragment length polymorphism
      Turkey (republic)
      Adult
      Aged
      Aged, 80 and over
      DNA Glycosylases
      DNA Repair
      DNA-Binding Proteins
      Genetic predisposition to disease
      Humans
      Middle Aged
      Polymerase Chain Reaction
      Polymorphism, Genetic
      Polymorphism, Restriction fragment length
      Turkey
      Urinary bladder neoplasms
      Permalink
      http://hdl.handle.net/11693/23684
      Collections
      • Department of Molecular Biology and Genetics 512
      • Institute of Materials Science and Nanotechnology (UNAM) 2098
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