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      Alkaline phosphatase-mimicking peptide nanofibers for osteogenic differentiation

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      Author
      Gülseren, Gülcihan
      Yasa, I. Ceren
      Ustahuseyin, Oya
      Tekin, E. Deniz
      Tekinay, Ayse B.
      Güler, Mustafa O.
      Date
      2015
      Source Title
      Biomacromolecules
      Print ISSN
      1525-7797
      Publisher
      American Chemical Society
      Volume
      16
      Issue
      7
      Pages
      2198 - 2208
      Language
      English
      Type
      Article
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      Abstract
      Recognition of molecules and regulation of extracellular matrix synthesis are some of the functions of enzymes in addition to their catalytic activity. While a diverse array of enzyme-like materials have been developed, these efforts have largely been confined to the imitation of the chemical structure and catalytic activity of the enzymes, and it is unclear whether enzyme-mimetic molecules can also be used to replicate the matrix-regulatory roles ordinarily performed by natural enzymes. Self-assembled peptide nanofibers can provide multifunctional enzyme-mimetic properties, as the active sequences of the target enzymes can be directly incorporated into the peptides. Here, we report enhanced bone regeneration efficiency through peptide nanofibers carrying both catalytic and matrix-regulatory functions of alkaline phosphatase, a versatile enzyme that plays a critical role in bone formation by regulating phosphate homeostasis and calcifiable bone matrix formation. Histidine presenting peptide nanostructures were developed to function as phosphatases. These molecules are able to catalyze phosphate hydrolysis and serve as bone-like nodule inducing scaffolds. Alkaline phosphatase-like peptide nanofibers enabled osteogenesis for both osteoblast-like and mesenchymal cell lines.
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      http://hdl.handle.net/11693/23525
      Published Version (Please cite this version)
      http://dx.doi.org/10.1021/acs.biomac.5b00593
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 201
      • Institute of Materials Science and Nanotechnology (UNAM) 1891
      • Nanotechnology Research Center (NANOTAM) 1049
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