The SOCS-1 gene methylation in chronic myeloid leukemia patients
Author
Hatirnaz, O.
Ure, U.
Ar, C.
Akyerli, C.
Soysal, T.
Ferhanoǧlu, B.
Özçelik, T.
Ozbek, U.
Date
2007Source Title
American Journal of Hematology
Print ISSN
0361-8609
Publisher
John Wiley & Sons, Inc.
Volume
82
Issue
8
Pages
729 - 730
Language
English
Type
ArticleItem Usage Stats
116
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Abstract
SOCS-1, an important protein in the JAK/STAT pathway, has a role in the down stream of BCR-ABL protein kinase. We investigated 56 CML patients and 16 controls for the methylation status of SOCS-1 gene promoter and Exon 2 regions. Exon 2 was found to be methylated in 58.9% of the patients and 93.8% of the controls [P = 0.020, OR = 0.121(0.015-0.957)%95CI]. The promoter region was found unmethylated in all patient samples and controls. Although previous studies revealed a relation between SOCS1 gene Exon-2 hypermethylation and CML development or progression, the results of this study showed no such correlation. On the contrary, our results might be indicating hypomethylation in CML patients, this hypothesis need to be studied in larger study population.
Keywords
BCR ABL proteinJanus kinase
STAT protein
suppressor of cytokine signaling 1
Article
Cancer growth
Cancer patient
Chronic myeloid leukemia
Controlled study
DNA methylation
Exon
Gene
Human
Leukemogenesis
Major clinical study
Male
Priority journal
Promoter region
Protein protein interaction
SOCS 1 gene
Adult
DNA Methylation
Exons
Female
Humans
Leukemia, Myeloid, Chronic
Male
Middle Aged
Suppressor of Cytokine Signaling Proteins
Permalink
http://hdl.handle.net/11693/23413Published Version (Please cite this version)
http://dx.doi.org/10.1002/ajh.20886Collections
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