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      The SOCS-1 gene methylation in chronic myeloid leukemia patients

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      Author
      Hatirnaz, O.
      Ure, U.
      Ar, C.
      Akyerli, C.
      Soysal, T.
      Ferhanoǧlu, B.
      Özçelik, T.
      Ozbek, U.
      Date
      2007
      Source Title
      American Journal of Hematology
      Print ISSN
      0361-8609
      Publisher
      John Wiley & Sons, Inc.
      Volume
      82
      Issue
      8
      Pages
      729 - 730
      Language
      English
      Type
      Article
      Item Usage Stats
      116
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      129
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      Abstract
      SOCS-1, an important protein in the JAK/STAT pathway, has a role in the down stream of BCR-ABL protein kinase. We investigated 56 CML patients and 16 controls for the methylation status of SOCS-1 gene promoter and Exon 2 regions. Exon 2 was found to be methylated in 58.9% of the patients and 93.8% of the controls [P = 0.020, OR = 0.121(0.015-0.957)%95CI]. The promoter region was found unmethylated in all patient samples and controls. Although previous studies revealed a relation between SOCS1 gene Exon-2 hypermethylation and CML development or progression, the results of this study showed no such correlation. On the contrary, our results might be indicating hypomethylation in CML patients, this hypothesis need to be studied in larger study population.
      Keywords
      BCR ABL protein
      Janus kinase
      STAT protein
      suppressor of cytokine signaling 1
      Article
      Cancer growth
      Cancer patient
      Chronic myeloid leukemia
      Controlled study
      DNA methylation
      Exon
      Gene
      Human
      Leukemogenesis
      Major clinical study
      Male
      Priority journal
      Promoter region
      Protein protein interaction
      SOCS 1 gene
      Adult
      DNA Methylation
      Exons
      Female
      Humans
      Leukemia, Myeloid, Chronic
      Male
      Middle Aged
      Suppressor of Cytokine Signaling Proteins
      Permalink
      http://hdl.handle.net/11693/23413
      Published Version (Please cite this version)
      http://dx.doi.org/10.1002/ajh.20886
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