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dc.contributor.authorBrushett, C.en_US
dc.contributor.authorQiu, B.en_US
dc.contributor.authorAtalar, E.en_US
dc.contributor.authorYang, X.en_US
dc.date.accessioned2016-02-08T10:10:38Z
dc.date.available2016-02-08T10:10:38Z
dc.date.issued2008en_US
dc.identifier.issn1053-1807
dc.identifier.urihttp://hdl.handle.net/11693/23234
dc.description.abstractPurpose: To evaluate the potential of using motexafin gadolinium (MGd) to characterize atherosclerotic plaques of deep-seated arteries with MRI. Materials and Methods: We exposed vascular endothelial cells (EC) and smooth muscle cells (SMC) in vitro to varying concentrations of MGd. The fluorescence properties of MGd were then exploited using confocal microscopy to image exposed cells. For an in vivo validation study, we performed surface coil-based and intravascular coil-based high-resolution MRI of the iliac arteries and the abdominal aorta of three atherosclerotic Yucatan pigs. Subsequently, MGd enhancement of the target vessel walls was quantitatively evaluated and MR images were correlated with histology of the target vessels. Results: The in vitro study confirmed the intracellularization of MGd in both cell types and determined the optimum MGd dosage of 0.004 mmol/kg that produced the sufficiently high intracellular fluorescent intensity. The in vivo study showed a steady increase of MGd enhancement to approximately 25% at three hours postinjection of MGd. MRI showed areas of strong enhancement along the lumen boundary, which corresponded to fibrous tissue seen in histology. Conclusion: This study provides initial evidence that MGd may enhance MR vessel wall imaging for the characterization of plaque in deep-seated arteries.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of Magnetic Resonance Imagingen_US
dc.relation.isversionofhttps://doi.org/10.1002/jmri.21174en_US
dc.subjectAtherosclerotic cardiovascular diseaseen_US
dc.subjectMotexafin gadoliniumen_US
dc.subjectContrast agenten_US
dc.subjectVessel wallen_US
dc.subjectIntravascular MRIen_US
dc.titleHigh‐resolution MRI of deep‐seated atherosclerotic arteries using motexafin gadoliniumen_US
dc.typeArticleen_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.citation.spage246en_US
dc.citation.epage250en_US
dc.citation.volumeNumber27en_US
dc.citation.issueNumber1en_US
dc.identifier.doi10.1002/jmri.21174en_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.identifier.eissn1522-2586


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