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      • Department of Electrical and Electronics Engineering
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      Zeta potential: A surface electrical characteristic to probe the interaction of nanoparticles with normal and cancer human breast epithelial cells

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      Author(s)
      Zhang, Y.
      Yang, M.
      Portney, N. G.
      Cui, D.
      Budak, G.
      Özbay, Ekmel
      Ozkan, M.
      Ozkan, C. S.
      Date
      2008
      Source Title
      Biomedical Microdevices
      Print ISSN
      1387-2176
      Electronic ISSN
      1572-8781
      Publisher
      Springer New York LLC
      Volume
      10
      Issue
      2
      Pages
      321 - 328
      Language
      English
      Type
      Article
      Item Usage Stats
      214
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      850
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      Abstract
      We demonstrate the use of surface Zeta potential measurements as a new tool to investigate the interactions of iron oxide nanoparticles and cowpea mosaic virus (CPMV) nanoparticles with human normal breast epithelial cells (MCF10A) and cancer breast epithelial cells (MCF7) respectively. A substantial understanding in the interaction of nanoparticles with normal and cancer cells in vitro will enable the capabilities of improving diagnostic and treatment methods in cancer research, such as imaging and targeted drug delivery. A theoretical Zeta potential model is first established to show the effects of binding process and internalization process during the nanoparticle uptake by cells and the possible trends of Zeta potential change is predicted for different cell endocytosis capacities. The corresponding changes of total surface charge of cells in the form of Zeta potential measurements were then reported after incubated respectively with iron oxide nanoparticles and CPMV nanoparticles. As observed, after MCF7 and MCF10A cells were incubated respectively with two types of nanoparticles, the significant differences in their surface charge change indicate the potential role of Zeta potential as a valuable biological signature in studying the cellular interaction of nanoparticles, as well as specific cell functionality.
      Keywords
      Zeta potential
      Normal breast cells
      Cancer breast cells
      Surface charge
      Iron oxide nanoparticles
      CPMV nanoparticles
      Cell endocytosis
      Permalink
      http://hdl.handle.net/11693/23143
      Published Version (Please cite this version)
      http://doi.org/10.1007/s10544-007-9139-2
      Collections
      • Department of Electrical and Electronics Engineering 3863
      • Department of Physics 2484
      • Institute of Materials Science and Nanotechnology (UNAM) 2098
      • Nanotechnology Research Center (NANOTAM) 1125
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