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      Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester

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      Author(s)
      Akturk, M.
      Altinova, A.E.
      Mert I.
      Buyukkagnici, U.
      Sargin, A.
      Arslan, M.
      Danisman, N.
      Date
      2008
      Source Title
      Journal of Endocrinological Investigation
      Print ISSN
      0391-4097
      Volume
      31
      Issue
      7
      Pages
      610 - 613
      Language
      English
      Type
      Article
      Item Usage Stats
      124
      views
      111
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      Abstract
      Our aim is to investigate visfatin concentration and its relationship to glycated hemoglobin (HbA1c), insulin resistance, lipid parameters, and neonatal birth weight in women with gestational diabetes mellitus (GDM). In our study group, there were 47 women with GDM and 31 women with normal glucose tolerance (NGT) between 33-39 weeks of gestation. Plasma visfatin levels were significantly decreased in pregnant women with GDM compared to those with NGT (p=0.001). Homeostasis model assessment-insulin resistance (HOMA-IR) levels were higher in the GDM group than in the NGT group (p=0.006). In all subjects, plasma visfatin levels were negatively correlated with HOMA-IR, post-prandial blood glucose, triglycerides, and VLDL cholesterol (p<0.05). We did not observe any statistically significant correlation between the plasma visfatin levels and the selected parameters in the GDM group, but in the NGT group plasma visfatin levels were negatively correlated with HOMA-IR (r=-0.36, p=0.04). There was no correlation between visfatin concentrations and fetal birth weight in either group (p>0.05). By regression analysis, having GDM was found to be the only significant determinant (t=3.5, p=0.001) of visfatin concentration (R=0.39, r2=0.15). We conclude that women with GDM have significantly decreased visfatin concentrations in the third trimester. Future studies are required to establish the exact role of visfatin in the pathogenesis of GDM. ©2008, Editrice Kurtis.
      Keywords
      Birth weight
      Gestational diabetes mellitus
      HOMA-IR
      Third trimester
      Visfatin
      glucose
      hemoglobin A1c
      high density lipoprotein cholesterol
      low density lipoprotein cholesterol
      triacylglycerol
      very low density lipoprotein cholesterol
      visfatin
      adult
      article
      birth weight
      cholesterol blood level
      clinical article
      controlled study
      female
      glucose blood level
      glucose tolerance
      hemoglobin determination
      human
      insulin resistance
      insulin treatment
      maternal blood
      normal glucose tolerance
      nutritional support
      pregnancy diabetes mellitus
      protein blood level
      third trimester pregnancy
      triacylglycerol blood level
      Adult
      Diabetes, Gestational
      Female
      Gestational Age
      Hemoglobin A, Glycosylated
      Humans
      Nicotinamide Phosphoribosyltransferase
      Pregnancy
      Pregnancy Trimester, Third
      Statistics as Topic
      Permalink
      http://hdl.handle.net/11693/23065
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      • Department of Chemistry 640
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