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dc.contributor.authorSuer, E.en_US
dc.contributor.authorSayrac, S.en_US
dc.contributor.authorSarinay, E.en_US
dc.contributor.authorOzturk H.E.en_US
dc.contributor.authorTurkoz, M.en_US
dc.contributor.authorIchinose, A.en_US
dc.contributor.authorNagatake, T.en_US
dc.contributor.authorAhmed, K.en_US
dc.date.accessioned2016-02-08T10:08:18Z
dc.date.available2016-02-08T10:08:18Z
dc.date.issued2008en_US
dc.identifier.issn1341321X
dc.identifier.urihttp://hdl.handle.net/11693/23052
dc.description.abstractS-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria. © 2008 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of Infection and Chemotherapyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s10156-008-0626-zen_US
dc.subjectEpithelial cellsen_US
dc.subjectHumanen_US
dc.subjectS-carboxymethylcysteineen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.subjectcarbocisteineen_US
dc.subjectpenicillin Gen_US
dc.subjectadulten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectantibiotic resistanceen_US
dc.subjectarticleen_US
dc.subjectbacterial virulenceen_US
dc.subjectbacterium adherenceen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectelectron microscopyen_US
dc.subjectepithelium cellen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectmaleen_US
dc.subjectminimum inhibitory concentrationen_US
dc.subjectmortalityen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectnormal humanen_US
dc.subjectpenicillin resistanceen_US
dc.subjectpharynxen_US
dc.subjectrespiratory tract infectionen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.subjectAnimalsen_US
dc.subjectBacterial Adhesionen_US
dc.subjectCarbocysteineen_US
dc.subjectEpithelial Cellsen_US
dc.subjectExpectorantsen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMiceen_US
dc.subjectPharynxen_US
dc.subjectRespiratory Tract Infectionsen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.titleVariation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteineen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Genetics
dc.citation.spage333en_US
dc.citation.epage336en_US
dc.citation.volumeNumber14en_US
dc.citation.issueNumber4en_US
dc.identifier.doi10.1007/s10156-008-0626-zen_US


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