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      A role for LYNX2 in anxiety-related behavior

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      Author
      Tekinay, A.B.
      Nong, Y.
      Miwa J.M.
      Lieberam I.
      Ibanez-Tallon I.
      Greengard P.
      Heintz, N.
      Date
      2009
      Source Title
      Proceedings of the National Academy of Sciences of the United States of America
      Print ISSN
      0027-8424
      Volume
      106
      Issue
      11
      Pages
      4477 - 4482
      Language
      English
      Type
      Article
      Item Usage Stats
      177
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      133
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      Abstract
      Anxiety disorders are the most prevalent mental disorders in developed societies. Although roles for the prefrontal cortex, amygdala, hippocampus and mediodorsal thalamus in anxiety disorders are well documented, molecular mechanisms contributing to the functions of these structures are poorly understood. Here we report that deletion of Lynx2, a mammalian prototoxin gene that is expressed at high levels in anxiety associated brain areas, results in elevated anxiety-like behaviors. We show that LYNX2 can bind to and modulate neuronal nicotinic receptors, and that loss of Lynx2 alters the actions of nicotine on glutamatergic signaling in the prefrontal cortex. Our data identify Lynx2 as an important component of the molecular mechanisms that control anxiety, and suggest that altered glutamatergic signaling in the prefrontal cortex of Lynx2 mutant mice contributes to increased anxiety-related behaviors.
      Keywords
      Anxiety
      LYNX2
      Nicotinic
      Prefrontal cortex
      glutamic acid
      lynx2 protein
      nicotine
      nicotinic receptor
      protein
      unclassified drug
      amygdaloid nucleus
      animal experiment
      animal tissue
      anxiety disorder
      article
      controlled study
      disease association
      gene
      gene deletion
      gene expression
      gene function
      gene loss
      hippocampus
      human
      human cell
      lynx2 gene
      molecular mechanics
      mouse
      neurotransmission
      nonhuman
      prefrontal cortex
      priority journal
      protein localization
      protein protein interaction
      receptor binding
      regulator gene
      thalamus dorsomedial nucleus
      Animals
      Anxiety
      Anxiety Disorders
      Behavior, Animal
      Glutamic Acid
      Membrane Glycoproteins
      Mice
      Mice, Mutant Strains
      Neuropeptides
      Protein Binding
      Receptors, Nicotinic
      Synaptic Transmission
      Mammalia
      Mus
      Permalink
      http://hdl.handle.net/11693/22803
      Published Version (Please cite this version)
      http://dx.doi.org/10.1073/pnas.0813109106
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      • Institute of Materials Science and Nanotechnology (UNAM) 1831
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