Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases
Date
2009
Authors
Chabchoub, G.
Uz, E.
Maalej, A.
Mustafa, C. A.
Rebai, A.
Mnif, M.
Bahloul, Z.
Farid, N. R.
Ozcelik, T.
Ayadi, H.
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Abstract
Introduction The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases.
Source Title
Arthritis Research and Therapy
Publisher
BioMed Central
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Keywords
Androgen receptor, Cyclic citrullinated peptide antibody, Hydroxychloroquine, Methotrexate, Penicillamine, Rheumatoid factor, Autoantibody, Allele, Autoimmune thyroiditis, Chromosome analysis, Controlled study, Female, Genetic association, Genetic predisposition, Human, Immunosuppressive treatment, Major clinical study, Phenotype, Polymerase chain reaction, X chromosome inactivation, Autoimmune disease, Blood, Enzyme linked immunosorbent assay, Genetics, Middle aged, Rheumatoid arthritis, Thyroid disease, X chromosome, Adult, Arthritis, Rheumatoid, Autoantibodies, Autoimmune Diseases, Chromosomes, Human, X, Enzyme-Linked Immunosorbent Assay, Fluorescent Antibody Technique, Genetic Predisposition to Disease, Humans, Polymerase Chain Reaction, Thyroid Diseases, Tunisia
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Language
English