Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases
Mustafa, C. A.
Farid, N. R.
Arthritis Research and Therapy
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Introduction The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases.
Cyclic citrullinated peptide antibody
Major clinical study
Polymerase chain reaction
X chromosome inactivation
Enzyme linked immunosorbent assay
Chromosomes, Human, X
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Genetic Predisposition to Disease
Polymerase Chain Reaction
Published Version (Please cite this version)http://dx.doi.org/10.1186/ar2759
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Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity Ozcelik, T.; Uz, E.; Akyerli, C. B.; Bagislar, S.; Mustafa, C. A.; Gursoy, A.; Akarsu, N.; Toruner, G.; Kamel, N.; Gullu, S. (Nature Publishing Group, 2006)The etiologic factors in the development of autoimmune thyroid diseases (AITDs) are not fully understood. We investigated the role of skewed X-chromosome inactivation (XCI) mosaicism in female predisposition to AITDs. One ...
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