Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases

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Author
Chabchoub, G.
Uz, E.
Maalej, A.
Mustafa, C. A.
Rebai, A.
Mnif, M.
Bahloul, Z.
Farid, N. R.
Ozcelik, T.
Ayadi, H.
Date
2009
Source Title
Arthritis Research and Therapy
Print ISSN
1478-6362
Publisher
BioMed Central
Volume
11
Issue
4
Pages
1 - 8
Language
English
Type
Article
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Abstract
Introduction The majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases.
Keywords
Androgen receptor
Cyclic citrullinated peptide antibody
Hydroxychloroquine
Methotrexate
Penicillamine
Rheumatoid factor
Autoantibody
Allele
Autoimmune thyroiditis
Chromosome analysis
Controlled study
Female
Genetic association
Genetic predisposition
Human
Immunosuppressive treatment
Major clinical study
Phenotype
Polymerase chain reaction
X chromosome inactivation
Autoimmune disease
Blood
Enzyme linked immunosorbent assay
Genetics
Middle aged
Rheumatoid arthritis
Thyroid disease
X chromosome
Adult
Arthritis, Rheumatoid
Autoantibodies
Autoimmune Diseases
Chromosomes, Human, X
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Genetic Predisposition to Disease
Humans
Polymerase Chain Reaction
Thyroid Diseases
Tunisia
Permalink
http://hdl.handle.net/11693/22696
Published Version (Please cite this version)
http://dx.doi.org/10.1186/ar2759
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