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      • Faculty of Science
      • Department of Molecular Biology and Genetics
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      Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis

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      Author(s)
      Uz, E.
      Mustafa, C.
      Topaloglu, R.
      Bilginer, Y.
      Dursun, A.
      Kasapcopur, O.
      Ozen, S.
      Bakkaloglu, A.
      Ozcelik, T.
      Date
      2009
      Source Title
      Arthritis and Rheumatism
      Print ISSN
      2326-5205
      Publisher
      John Wiley & Sons, Inc.
      Volume
      60
      Issue
      11
      Pages
      3410 - 3412
      Language
      English
      Type
      Article
      Item Usage Stats
      143
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      104
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      Abstract
      Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.
      Keywords
      Androgen receptor
      DNA
      Immunosuppressive agent
      Methotrexate
      Nonsteroid antiinflammatory agent
      Article
      Blood sampling
      Controlled study
      DNA polymorphism
      Female
      Gene frequency
      Human
      Juvenile rheumatoid arthritis
      Major clinical study
      Priority journal
      X chromosome inactivation
      Adolescent
      Arthritis, Juvenile Rheumatoid
      Case-Control Studies
      Child
      Child, Preschool
      Chromosomes, Human, X
      Female
      Genetic Predisposition to Disease
      Genotype
      Heterozygote
      Humans
      Mutation
      Receptors, Androgen
      Risk Factors
      X Chromosome Inactivation
      Permalink
      http://hdl.handle.net/11693/22574
      Published Version (Please cite this version)
      http://dx.doi.org/10.1002/art.24956
      Collections
      • Department of Molecular Biology and Genetics 468
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
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