Increased frequency of extremely skewed X chromosome inactivation in juvenile idiopathic arthritis
Author
Uz, E.
Mustafa, C.
Topaloglu, R.
Bilginer, Y.
Dursun, A.
Kasapcopur, O.
Ozen, S.
Bakkaloglu, A.
Ozcelik, T.
Date
2009Source Title
Arthritis and Rheumatism
Print ISSN
2326-5205
Publisher
John Wiley & Sons, Inc.
Volume
60
Issue
11
Pages
3410 - 3412
Language
English
Type
ArticleItem Usage Stats
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Abstract
Objective. Juvenile idiopathic arthritis (JIA) is a childhood rheumatic disease of unknown etiology. Two subgroups of JIA, i.e., oligoarticular and polyarticular, are thought to have an autoimmune component, and show a higher female:male ratio. Skewed X chromosome inactivation (XCI) has previously been shown to be associated with scleroderma and autoimmune thyroiditis, 2 autoimmune disorders occurring predominantly in females. This study was undertaken to extend the analysis to the pediatric age group and to determine the XCI profiles of patients with JIA.
Keywords
Androgen receptorDNA
Immunosuppressive agent
Methotrexate
Nonsteroid antiinflammatory agent
Article
Blood sampling
Controlled study
DNA polymorphism
Female
Gene frequency
Human
Juvenile rheumatoid arthritis
Major clinical study
Priority journal
X chromosome inactivation
Adolescent
Arthritis, Juvenile Rheumatoid
Case-Control Studies
Child
Child, Preschool
Chromosomes, Human, X
Female
Genetic Predisposition to Disease
Genotype
Heterozygote
Humans
Mutation
Receptors, Androgen
Risk Factors
X Chromosome Inactivation