• About
  • Policies
  • What is open access
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Molecular Biology and Genetics
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Molecular Biology and Genetics
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes α7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons

      Thumbnail
      View / Download
      2.4 Mb
      Author(s)
      Hruska, M.
      Keefe J.
      Wert, D.
      Tekinay, A.B.
      Hulce J.J.
      Ibañez-Tallon I.
      Nishi, R.
      Date
      2009
      Source Title
      Journal of Neuroscience
      Print ISSN
      0270-6474
      Volume
      29
      Issue
      47
      Pages
      14847 - 14854
      Language
      English
      Type
      Article
      Item Usage Stats
      113
      views
      80
      downloads
      Abstract
      Vertebrate α-bungarotoxin-like molecules of the Ly-6 superfamily have been implicated as balancers of activity and survival in the adult nervous system. To determine whether a member of this family could be involved in the development of the avian ciliary ganglion, we identified 6 Gallus genes by their homology in structure to mouse lynx1 and lynx2. One of these genes, an ortholog of prostate stem cell antigen (psca), is barely detectable at embryonic day (E) 8, before neuronal cell loss in the ciliary ganglion, but increases > 100-fold as the number of neurons begins to decline between E9 and E14. PSCA is highly expressed in chicken and mouse telencephalon and peripheral ganglia and correlates with expression of α7-containing nicotinic acetylcholine receptors (α7-nAChRs). Misexpressing PSCA before cell death in the ciliary ganglion blocks α7-nAChR activation by nicotine and rescues the choroid subpopulation from dying. Thus, PSCA, a molecule previously identified as a marker of prostate cancer, is a member of the Ly-6 neurotoxin-like family in the nervous system, and is likely to play a role as a modulator of α7 signaling-induced cell death during development. Copyright © 2009 Society for Neuroscience.
      Keywords
      alpha bungarotoxin
      bungarotoxin receptor
      complementary DNA
      neurotoxin
      prostate stem cell antigen
      RNA
      virus vector
      animal tissue
      apoptosis
      article
      chick embryo
      ciliary ganglion
      controlled study
      embryo development
      gene expression
      immunohistochemistry
      mouse
      nerve cell necrosis
      nervous system development
      nonhuman
      parasympathetic nerve cell
      priority journal
      prostate cancer
      real time polymerase chain reaction
      telencephalon
      Amino Acid Sequence
      Animals
      Apoptosis
      Avian Proteins
      Base Sequence
      Chickens
      Ganglia, Parasympathetic
      Gene Expression Regulation, Developmental
      Membrane Glycoproteins
      Mice
      Molecular Sequence Data
      Neoplasm Proteins
      Neurons
      Neuropeptides
      Neurotoxins
      Nicotinic Agonists
      Nicotinic Antagonists
      Receptors, Nicotinic
      Sequence Homology, Nucleic Acid
      Telencephalon
      Permalink
      http://hdl.handle.net/11693/22562
      Published Version (Please cite this version)
      http://dx.doi.org/10.1523/JNEUROSCI.2271-09.2009
      Collections
      • Department of Molecular Biology and Genetics 468
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
      Show full item record

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartments

      My Account

      LoginRegister

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 1771
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy