In vitro biocompatibility of plasma-aided surface-modified 316L stainless steel for intracoronary stents
Author
Bayram, C.
Mizrak, A.K.
Aktürk, S.
Kurşaklioǧlu H.
Iyisoy, A.
Ifran, A.
Denkbaş, E.B.
Date
2010Source Title
Biomedical Materials
Print ISSN
17486041
Publisher
Institute of Physics Publishing
Volume
5
Issue
5
Language
English
Type
ArticleItem Usage Stats
119
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views
122
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Abstract
316L-type stainless steel is a raw material mostly used for manufacturing metallic coronary stents. The purpose of this study was to examine the chemical, wettability, cytotoxic and haemocompatibility properties of 316L stainless steel stents which were modified by plasma polymerization. Six different polymeric compounds, polyethylene glycol, 2-hydroxyethyl methacrylate, ethylenediamine, acrylic acid, hexamethyldisilane and hexamethyldisiloxane, were used in a radio frequency glow discharge plasma polymerization system. As a model antiproliferative drug, mitomycin-C was chosen for covalent coupling onto the stent surface. Modified SS 316L stents were characterized by water contact angle measurements (goniometer) and x-ray photoelectron spectroscopy. C1s binding energies showed a good correlation with the literature. Haemocompatibility tests of coated SS 316L stents showed significant latency (t-test, p < 0.05) with respect to SS 316L and control groups in each test. © 2010 IOP Publishing Ltd.
Keywords
Angle measurementBinding energy
Biocompatibility
Carboxylic acids
Contact angle
Corrosion resistant alloys
Glow discharges
Organic acids
Plasma polymerization
Polyethylene glycols
Polyethylene oxides
Polyethylenes
Polymers
X ray photoelectron spectroscopy
2-hydroxyethyl methacrylate
316 L stainless steel
Acrylic acids
Anti-proliferative
Control groups
Coronary stents
Covalent couplings
Cytotoxic
Ethylene diamine
Good correlations
Haemocompatibility
Hexamethyl disiloxane
Hexamethyldisilanes
In-vitro
Intra-coronary stents
Mitomycin C
Polymeric compounds
Polymerization systems
Radio frequency glow discharge
Surface-modified
Water contact angle measurement
Stainless steel
2 hydroxyethyl methacrylate
acrylic acid
ethylenediamine
hexamethyldisilane
hexamethyldisiloxane
macrogol
mitomycin C
silane derivative
stainless steel
unclassified drug
2 hydroxyethyl methacrylate
antineoplastic antibiotic
biomaterial
macrogol derivative
methacrylic acid derivative
mitomycin
polymer
animal cell
article
biocompatibility
contact angle
controlled study
coronary stent
cytotoxicity
human
mouse
nonhuman
physical chemistry
plasma
polymerization
surface property
wettability
blood
blood clotting test
body fluid
chemistry
comparative study
stent
toxicity testing
X ray photoelectron spectroscopy
Antibiotics, Antineoplastic
Blood
Blood Coagulation Tests
Body Fluids
Coated Materials, Biocompatible
Humans
Methacrylates
Mitomycin
Photoelectron Spectroscopy
Polyethylene Glycols
Polymers
Stainless Steel
Stents
Surface Properties
Toxicity Tests
Wettability
Permalink
http://hdl.handle.net/11693/22464Published Version (Please cite this version)
http://dx.doi.org/10.1088/1748-6041/5/5/055007Collections
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