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      In vitro biocompatibility of plasma-aided surface-modified 316L stainless steel for intracoronary stents

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      Author
      Bayram, C.
      Mizrak, A.K.
      Aktürk, S.
      Kurşaklioǧlu H.
      Iyisoy, A.
      Ifran, A.
      Denkbaş, E.B.
      Date
      2010
      Source Title
      Biomedical Materials
      Print ISSN
      17486041
      Publisher
      Institute of Physics Publishing
      Volume
      5
      Issue
      5
      Language
      English
      Type
      Article
      Item Usage Stats
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      122
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      Abstract
      316L-type stainless steel is a raw material mostly used for manufacturing metallic coronary stents. The purpose of this study was to examine the chemical, wettability, cytotoxic and haemocompatibility properties of 316L stainless steel stents which were modified by plasma polymerization. Six different polymeric compounds, polyethylene glycol, 2-hydroxyethyl methacrylate, ethylenediamine, acrylic acid, hexamethyldisilane and hexamethyldisiloxane, were used in a radio frequency glow discharge plasma polymerization system. As a model antiproliferative drug, mitomycin-C was chosen for covalent coupling onto the stent surface. Modified SS 316L stents were characterized by water contact angle measurements (goniometer) and x-ray photoelectron spectroscopy. C1s binding energies showed a good correlation with the literature. Haemocompatibility tests of coated SS 316L stents showed significant latency (t-test, p < 0.05) with respect to SS 316L and control groups in each test. © 2010 IOP Publishing Ltd.
      Keywords
      Angle measurement
      Binding energy
      Biocompatibility
      Carboxylic acids
      Contact angle
      Corrosion resistant alloys
      Glow discharges
      Organic acids
      Plasma polymerization
      Polyethylene glycols
      Polyethylene oxides
      Polyethylenes
      Polymers
      X ray photoelectron spectroscopy
      2-hydroxyethyl methacrylate
      316 L stainless steel
      Acrylic acids
      Anti-proliferative
      Control groups
      Coronary stents
      Covalent couplings
      Cytotoxic
      Ethylene diamine
      Good correlations
      Haemocompatibility
      Hexamethyl disiloxane
      Hexamethyldisilanes
      In-vitro
      Intra-coronary stents
      Mitomycin C
      Polymeric compounds
      Polymerization systems
      Radio frequency glow discharge
      Surface-modified
      Water contact angle measurement
      Stainless steel
      2 hydroxyethyl methacrylate
      acrylic acid
      ethylenediamine
      hexamethyldisilane
      hexamethyldisiloxane
      macrogol
      mitomycin C
      silane derivative
      stainless steel
      unclassified drug
      2 hydroxyethyl methacrylate
      antineoplastic antibiotic
      biomaterial
      macrogol derivative
      methacrylic acid derivative
      mitomycin
      polymer
      animal cell
      article
      biocompatibility
      contact angle
      controlled study
      coronary stent
      cytotoxicity
      human
      mouse
      nonhuman
      physical chemistry
      plasma
      polymerization
      surface property
      wettability
      blood
      blood clotting test
      body fluid
      chemistry
      comparative study
      stent
      toxicity testing
      X ray photoelectron spectroscopy
      Antibiotics, Antineoplastic
      Blood
      Blood Coagulation Tests
      Body Fluids
      Coated Materials, Biocompatible
      Humans
      Methacrylates
      Mitomycin
      Photoelectron Spectroscopy
      Polyethylene Glycols
      Polymers
      Stainless Steel
      Stents
      Surface Properties
      Toxicity Tests
      Wettability
      Permalink
      http://hdl.handle.net/11693/22464
      Published Version (Please cite this version)
      http://dx.doi.org/10.1088/1748-6041/5/5/055007
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      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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