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dc.contributor.authorDogrul, A.B.en_US
dc.contributor.authorColakoglu, T.en_US
dc.contributor.authorKosemehmetoglu, K.en_US
dc.contributor.authorBirben, E.en_US
dc.contributor.authorYaman, E.en_US
dc.contributor.authorGedikoglu G.en_US
dc.contributor.authorAbbasoglu O.en_US
dc.date.accessioned2016-02-08T10:00:09Z
dc.date.available2016-02-08T10:00:09Z
dc.date.issued2010en_US
dc.identifier.issn0039-6060
dc.identifier.urihttp://hdl.handle.net/11693/22444
dc.description.abstractBackground: The aim of this study was to evaluate the antiangiogenic response and its relation to regeneration and angiogenesis after 70% hepatectomy in a rat model. Methods: Sixty-four Wistar albino rats were included in the study. Animals were allocated into 8 groups (n = 8). After a 70% hepatectomy, liver regeneration, angiogenesis, and antiangiogenic response were evaluated in the remnant liver on days 0, 1, 2, 3, 5, 7, 10, and 14. Regeneration and angiogenesis were determined with immunoreactivity to proliferating cell nuclear antigen and vascular endothelial growth factor. Antiangiogenic response was evaluated by detecting collagen 18 m RNA with reverse transcriptase polymerase chain reaction. Results: We showed that liver regeneration peaked at day 1, whereas angiogenesis in the periportal and perisinusoidal areas reached their peak values on days 3 and 7, respectively. Both regeneration and angiogenic activity around perisinusoidal hepatocytes returned to basal activity on the day 10. Antiangiogenic response first appeared on day 5, reached a peak on day 10, and returned to basal values on day 14. Conclusion: Collagen18 mRNA expression is present in the normal liver during the regenerative process. We suggest that the stimulus that causes the cessation of regeneration process may come from hepatocytes, and collagen 18 produced by hepatocytes may modulate this event by inhibiting the angiogenesis. © 2010 Mosby, Inc. All rights reserved.en_US
dc.language.isoEnglishen_US
dc.source.titleSurgeryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.surg.2009.10.015en_US
dc.subjectcell nucleus antigenen_US
dc.subjectcollagenen_US
dc.subjectcollagen 18en_US
dc.subjectmessenger RNAen_US
dc.subjectunclassified drugen_US
dc.subjectvasculotropinen_US
dc.subjectangiogenesisen_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectcell activityen_US
dc.subjectcell stimulationen_US
dc.subjectcontrolled studyen_US
dc.subjectexperimental modelen_US
dc.subjectexperimental surgeryen_US
dc.subjectfemaleen_US
dc.subjectgene expressionen_US
dc.subjectimmunoreactivityen_US
dc.subjectliver cellen_US
dc.subjectliver regenerationen_US
dc.subjectliver resectionen_US
dc.subjectliver sinusoiden_US
dc.subjectnonhumanen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjectreverse transcription polymerase chain reactionen_US
dc.subjectstimulusen_US
dc.subjecttreatment responseen_US
dc.subjectWistar raten_US
dc.subjectAngiogenesis Inhibitorsen_US
dc.subjectAnimalsen_US
dc.subjectCollagen Type XVIIIen_US
dc.subjectFemaleen_US
dc.subjectHepatectomyen_US
dc.subjectHepatocytesen_US
dc.subjectLiveren_US
dc.subjectLiver Regenerationen_US
dc.subjectNeovascularization, Physiologicen_US
dc.subjectProliferating Cell Nuclear Antigenen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectReverse Transcriptase Polymerase Chain Reactionen_US
dc.subjectVascular Endothelial Growth Factor Aen_US
dc.titleAntiangiogenic response after 70% hepatectomy and its relationship with hepatic regeneration and angiogenesis in ratsen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Genetics
dc.citation.spage288en_US
dc.citation.epage294en_US
dc.citation.volumeNumber147en_US
dc.citation.issueNumber2en_US
dc.identifier.doi10.1016/j.surg.2009.10.015en_US


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