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dc.contributor.authorSag, D.en_US
dc.contributor.authorCekic, C.en_US
dc.contributor.authorWu, R.en_US
dc.contributor.authorLinden J.en_US
dc.contributor.authorHedrick, C.C.en_US
dc.date.accessioned2016-02-08T09:59:38Z
dc.date.available2016-02-08T09:59:38Z
dc.date.issued2015en_US
dc.identifier.issn20411723
dc.identifier.urihttp://hdl.handle.net/11693/22403
dc.description.abstractATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1-/- mice have dramatically suppressed subcutaneous MB49-bladder carcinoma and B16-melanoma growth and prolonged survival. We show that reduced tumour growth in Abcg1-/- mice is myeloid cell intrinsic and is associated with a phenotypic shift of the macrophages from a tumour-promoting M2 to a tumour-fighting M1 within the tumour. Abcg1-/- macrophages exhibit an intrinsic bias towards M1 polarization with increased NF-κB activation and direct cytotoxicity for tumour cells in vitro. Overall, our study demonstrates that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour, and illustrates a link between cholesterol homeostasis and cancer. © 2015 Macmillan Publishers Limited. All rights reserved.en_US
dc.language.isoEnglishen_US
dc.source.titleNature Communicationsen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ncomms7354en_US
dc.subjectABC transporter G1en_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectcanceren_US
dc.subjectcell organelleen_US
dc.subjecthomeostasisen_US
dc.subjectimmunityen_US
dc.subjectinhibitionen_US
dc.subjectorganic compounden_US
dc.subjectphenotypeen_US
dc.subjecttumoren_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectbladder carcinomaen_US
dc.subjectbone marrow cellen_US
dc.subjectcholesterol homeostasisen_US
dc.subjectcholesterol transporten_US
dc.subjectcytotoxicityen_US
dc.subjecthomeostasisen_US
dc.subjectin vitro studyen_US
dc.subjectmacrophage functionen_US
dc.subjectmelanoma B16en_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjecttumor cellen_US
dc.subjecttumor growthen_US
dc.subjecttumor immunityen_US
dc.subjectMusen_US
dc.titleThe cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunityen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Genetics
dc.citation.volumeNumber6en_US
dc.identifier.doi10.1038/ncomms7354en_US
dc.publisherNature Publishing Groupen_US


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