Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes
Author(s)
Date
2010Source Title
Endocrine
Print ISSN
1355008X
Volume
38
Issue
1
Pages
134 - 141
Language
English
Type
ArticleItem Usage Stats
172
views
views
143
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downloads
Abstract
As shown in the previous studies, asymmetric dimethylarginine (ADMA) is related to endothelial dysfunction, whereas high-sensitive C-reactive protein (hCRP) is the marker of inflammation. In our study, we investigated ADMA, hCRP, and homocysteine concentrations in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during late pregnancy. Fifty-four women with GDM and 69 women with NGT between 32 and 39 weeks of gestation were included in this study. ADMA, hCRP, homocysteine, lipid parameters, glycated hemoglobin (HbA1c) levels, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured. The plasma ADMA concentrations were significantly higher in GDM patients than in NGT subjects (P = 0.03) and the hCRP levels were also significantly increased in GDM group when compared with those in the NGT group (P = 0.008). However, plasma homocysteine levels did not differ between the groups (P = 0.4), while HOMA-IR, insulin, and triglyceride levels were higher in the GDM group than in the NGT group (P = 0.001, 0.002, and 0.02, respectively). The ADMA concentrations in the third trimester were positively correlated with the glucose levels the 50-g glucose challenge test (GCT) during 24-28 weeks in the whole group (r = 0.21, P = 0.02). Our results demonstrate that ADMA and hCRP are elevated in women with GDM during late pregnancy. Further studies are needed to clarify the significance and the underlying mechanisms of the elevated ADMA and hCRP levels in women with GDM. © 2010 Springer Science+Business Media, LLC.
Keywords
Asymmetric dimethylarginineGestational diabetes
High-sensitive C-reactive protein (hCRP)
Homocysteine
Insulin resistance
C reactive protein
glucose
glycosylated hemoglobin
hemoglobin A1c
homocysteine
insulin
lipid
n(g),n(g) dimethylarginine
triacylglycerol
adult
article
controlled study
diet therapy
female
gestational age
glucose tolerance
hemoglobin blood level
human
insulin blood level
insulin resistance
insulin treatment
lipid blood level
major clinical study
pregnancy diabetes mellitus
priority journal
protein blood level
triacylglycerol blood level
Adolescent
Adult
Arginine
C-Reactive Protein
Diabetes, Gestational
Female
Homocysteine
Humans
Insulin Resistance
Pregnancy
Pregnancy Trimester, Third
Young Adult
Permalink
http://hdl.handle.net/11693/22260Published Version (Please cite this version)
http://dx.doi.org/10.1007/s12020-010-9361-1Collections
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