• About
  • Policies
  • What is open access
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Molecular Biology and Genetics
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Molecular Biology and Genetics
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes

      Thumbnail
      View / Download
      253.1 Kb
      Author(s)
      Akturk, M.
      Altinova, A.
      Mert I.
      Dincel, A.
      Sargin, A.
      Buyukkagnici, U.
      Arslan, M.
      Danisman, N.
      Date
      2010
      Source Title
      Endocrine
      Print ISSN
      1355008X
      Volume
      38
      Issue
      1
      Pages
      134 - 141
      Language
      English
      Type
      Article
      Item Usage Stats
      172
      views
      143
      downloads
      Abstract
      As shown in the previous studies, asymmetric dimethylarginine (ADMA) is related to endothelial dysfunction, whereas high-sensitive C-reactive protein (hCRP) is the marker of inflammation. In our study, we investigated ADMA, hCRP, and homocysteine concentrations in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during late pregnancy. Fifty-four women with GDM and 69 women with NGT between 32 and 39 weeks of gestation were included in this study. ADMA, hCRP, homocysteine, lipid parameters, glycated hemoglobin (HbA1c) levels, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured. The plasma ADMA concentrations were significantly higher in GDM patients than in NGT subjects (P = 0.03) and the hCRP levels were also significantly increased in GDM group when compared with those in the NGT group (P = 0.008). However, plasma homocysteine levels did not differ between the groups (P = 0.4), while HOMA-IR, insulin, and triglyceride levels were higher in the GDM group than in the NGT group (P = 0.001, 0.002, and 0.02, respectively). The ADMA concentrations in the third trimester were positively correlated with the glucose levels the 50-g glucose challenge test (GCT) during 24-28 weeks in the whole group (r = 0.21, P = 0.02). Our results demonstrate that ADMA and hCRP are elevated in women with GDM during late pregnancy. Further studies are needed to clarify the significance and the underlying mechanisms of the elevated ADMA and hCRP levels in women with GDM. © 2010 Springer Science+Business Media, LLC.
      Keywords
      Asymmetric dimethylarginine
      Gestational diabetes
      High-sensitive C-reactive protein (hCRP)
      Homocysteine
      Insulin resistance
      C reactive protein
      glucose
      glycosylated hemoglobin
      hemoglobin A1c
      homocysteine
      insulin
      lipid
      n(g),n(g) dimethylarginine
      triacylglycerol
      adult
      article
      controlled study
      diet therapy
      female
      gestational age
      glucose tolerance
      hemoglobin blood level
      human
      insulin blood level
      insulin resistance
      insulin treatment
      lipid blood level
      major clinical study
      pregnancy diabetes mellitus
      priority journal
      protein blood level
      triacylglycerol blood level
      Adolescent
      Adult
      Arginine
      C-Reactive Protein
      Diabetes, Gestational
      Female
      Homocysteine
      Humans
      Insulin Resistance
      Pregnancy
      Pregnancy Trimester, Third
      Young Adult
      Permalink
      http://hdl.handle.net/11693/22260
      Published Version (Please cite this version)
      http://dx.doi.org/10.1007/s12020-010-9361-1
      Collections
      • Department of Molecular Biology and Genetics 468
      Show full item record

      Related items

      Showing items related by title, author, creator and subject.

      • Thumbnail

        Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester 

        Akturk, M.; Altinova, A.E.; Mert I.; Buyukkagnici, U.; Sargin, A.; Arslan, M.; Danisman, N. (2008)
        Our aim is to investigate visfatin concentration and its relationship to glycated hemoglobin (HbA1c), insulin resistance, lipid parameters, and neonatal birth weight in women with gestational diabetes mellitus (GDM). In ...
      • Thumbnail

        Na+/I-symporter and type 3 iodothyronine deiodinase gene expression in amniotic membrane and placenta and its relationship to maternal thyroid hormones 

        Akturk, M.; Oruc, A.S.; Danisman, N.; Erkek, S.; Buyukkagnici, U.; Unlu, E.; Tazebay, U.H. (2013)
        Placental type 3 iodothyronine deiodinase (D3) potentially protects the fetus from the elevated maternal thyroid hormones. Na+/I- symporter (NIS) is a plasma membrane glycoprotein, which mediates active iodide uptake. Our ...
      • Thumbnail

        Effect of six weeks aerobic training upon blood trace metals levels 

        Savaş, S.; Şenel, Ö.; Çelikkan, H.; Uǧraş, A.; Aksu, M. L. (2006)
        This study was carried out to investigate the effects of 6-week aerobic exercise program upon blood Zn and Cu levels. There were 12 male university students with an average age of 21.67+/-0.89 years and no regular training ...

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartments

      My Account

      LoginRegister

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 1771
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy