mESAdb: microRNA expression and sequence analysis database

Kaya, Koray D.; Karakülah, G.; Yakıcıer, Cengiz M.; Acar, Aybar C.; Konu, Özlen

doi:10.1093/nar/gkq1256

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Author

Kaya, Koray D.

Karakülah, G.

Yakıcıer, Cengiz M.

Acar, Aybar C.

Konu, Özlen

Date

2011

Source Title

Nucleic Acids Research

Print ISSN

0305-1048

Electronic ISSN

1362-4962

Publisher

Oxford University Press

Volume

Pages

D170 - D180

Language

English

Type

Article

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Abstract

MicroRNA expression and sequence analysis database (http://konulab.fen. bilkent.edu.tr/mirna/) (mESAdb) is a regularly updated database for the multivariate analysis of sequences and expression of microRNAs from multiple taxa. mESAdb is modular and has a user interface implemented in PHP and JavaScript and coupled with statistical analysis and visualization packages written for the R language. The database primarily comprises mature microRNA sequences and their target data, along with selected human, mouse and zebrafish expression data sets. mESAdb analysis modules allow (i) mining of microRNA expression data sets for subsets of microRNAs selected manually or by motif; (ii) pair-wise multivariate analysis of expression data sets within and between taxa; and (iii) association of microRNA subsets with annotation databases, HUGE Navigator, KEGG and GO. The use of existing and customized R packages facilitates future addition of data sets and analysis tools. Furthermore, the ability to upload and analyze user-specified data sets makes mESAdb an interactive and expandable analysis tool for microRNA sequence and expression data.

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