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      mESAdb: microRNA expression and sequence analysis database

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      Author(s)
      Kaya, Koray D.
      Karakülah, G.
      Yakıcıer, Cengiz M.
      Acar, Aybar C.
      Konu, Özlen
      Date
      2011
      Source Title
      Nucleic Acids Research
      Print ISSN
      0305-1048
      Electronic ISSN
      1362-4962
      Publisher
      Oxford University Press
      Volume
      39
      Pages
      D170 - D180
      Language
      English
      Type
      Article
      Item Usage Stats
      171
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      170
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      Abstract
      MicroRNA expression and sequence analysis database (http://konulab.fen. bilkent.edu.tr/mirna/) (mESAdb) is a regularly updated database for the multivariate analysis of sequences and expression of microRNAs from multiple taxa. mESAdb is modular and has a user interface implemented in PHP and JavaScript and coupled with statistical analysis and visualization packages written for the R language. The database primarily comprises mature microRNA sequences and their target data, along with selected human, mouse and zebrafish expression data sets. mESAdb analysis modules allow (i) mining of microRNA expression data sets for subsets of microRNAs selected manually or by motif; (ii) pair-wise multivariate analysis of expression data sets within and between taxa; and (iii) association of microRNA subsets with annotation databases, HUGE Navigator, KEGG and GO. The use of existing and customized R packages facilitates future addition of data sets and analysis tools. Furthermore, the ability to upload and analyze user-specified data sets makes mESAdb an interactive and expandable analysis tool for microRNA sequence and expression data.
      Keywords
      Computer interface
      Gene expression
      Gene function
      Genetic association
      Information processing
      MicroRNA expression and sequence analysis database
      Priority journal
      RNA sequence
      Sequence analysis
      Sequence database
      Statistical analysis
      Animals
      Databases
      Humans
      Mice
      MicroRNAs
      Software
      Systems Integration
      Danio rerio
      Permalink
      http://hdl.handle.net/11693/22055
      Published Version (Please cite this version)
      http://dx.doi.org/10.1093/nar/gkq1256
      Collections
      • Department of Computer Engineering 1435
      • Department of Molecular Biology and Genetics 468
      • Genetics and Biotechnology Research Center (BİLGEN) 16
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