Electrostatic effects on nanofiber formation of self-assembling peptide amphiphiles
Author
Toksoz, S.
Mammadov R.
Tekinay, A. B.
Güler, Mustafa O.
Date
2011Source Title
Journal of Colloid and Interface Science
Print ISSN
0021-9797
Publisher
Elsevier
Volume
356
Issue
1
Pages
131 - 137
Language
English
Type
ArticleItem Usage Stats
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Abstract
Self-assembling peptide amphiphile molecules have been of interest to various tissue engineering studies. These molecules self-assemble into nanofibers which organize into three-dimensional networks to form hydrocolloid systems mimicking the extracellular matrix. The formation of nanofibers is affected by the electrostatic interactions among the peptides. In this work, we studied the effect of charged groups on the peptides on nanofiber formation. The self-assembly process was studied by pH and zeta potential measurements, FT-IR, circular dichroism, rheology, atomic force microscopy, scanning electron microscopy and transmission electron microscopy. The aggregation of the peptides was triggered upon neutralization of the charged residues by pH change or addition of electrolyte or biomacromolecules. Understanding the controlled formation of the hydrocolloid gels composed of peptide amphiphile nanofibers can lead us to develop in situ gel forming bioactive collagen mimetic nanofibers for various tissue engineering studies including bioactive surface coatings. © 2010 Elsevier Inc.
Keywords
Electrostatic interactionsGel
Nanofiber
Peptide
Peptide amphiphile
Self-assembly
Bioactive surfaces
Biomacromolecules
Charged groups
Charged residues
Circular dichroism
Electrostatic effect
Electrostatic interactions
Extracellular matrices
In-situ
Peptide amphiphiles
pH change
Self-assemble
Three-dimensional networks
Zeta potential measurements
Atomic force microscopy
Biomimetics
Coatings
Dichroism
Electrostatics
Tissue engineering
Transmission electron microscopy
Zeta potential
Hydrogen-Ion Concentration
Permalink
http://hdl.handle.net/11693/21969Published Version (Please cite this version)
http://dx.doi.org/10.1016/j.jcis.20http://dx.doi.org/10.12.076Collections
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