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      Electrostatic effects on nanofiber formation of self-assembling peptide amphiphiles

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      Author
      Toksoz, S.
      Mammadov R.
      Tekinay, A. B.
      Güler, Mustafa O.
      Date
      2011
      Source Title
      Journal of Colloid and Interface Science
      Print ISSN
      0021-9797
      Publisher
      Elsevier
      Volume
      356
      Issue
      1
      Pages
      131 - 137
      Language
      English
      Type
      Article
      Item Usage Stats
      98
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      82
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      Abstract
      Self-assembling peptide amphiphile molecules have been of interest to various tissue engineering studies. These molecules self-assemble into nanofibers which organize into three-dimensional networks to form hydrocolloid systems mimicking the extracellular matrix. The formation of nanofibers is affected by the electrostatic interactions among the peptides. In this work, we studied the effect of charged groups on the peptides on nanofiber formation. The self-assembly process was studied by pH and zeta potential measurements, FT-IR, circular dichroism, rheology, atomic force microscopy, scanning electron microscopy and transmission electron microscopy. The aggregation of the peptides was triggered upon neutralization of the charged residues by pH change or addition of electrolyte or biomacromolecules. Understanding the controlled formation of the hydrocolloid gels composed of peptide amphiphile nanofibers can lead us to develop in situ gel forming bioactive collagen mimetic nanofibers for various tissue engineering studies including bioactive surface coatings. © 2010 Elsevier Inc.
      Keywords
      Electrostatic interactions
      Gel
      Nanofiber
      Peptide
      Peptide amphiphile
      Self-assembly
      Bioactive surfaces
      Biomacromolecules
      Charged groups
      Charged residues
      Circular dichroism
      Electrostatic effect
      Electrostatic interactions
      Extracellular matrices
      In-situ
      Peptide amphiphiles
      pH change
      Self-assemble
      Three-dimensional networks
      Zeta potential measurements
      Atomic force microscopy
      Biomimetics
      Coatings
      Dichroism
      Electrostatics
      Tissue engineering
      Transmission electron microscopy
      Zeta potential
      Hydrogen-Ion Concentration
      Permalink
      http://hdl.handle.net/11693/21969
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.jcis.20http://dx.doi.org/10.12.076
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      • Institute of Materials Science and Nanotechnology (UNAM) 1831
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