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      Development of a thulium (Tm:YAP) laser system for brain tissue ablation

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      Author
      Bilici, T.
      Mutlu, S.
      Kalaycioglu H.
      Kurt, A.
      Sennaroglu, A.
      Gulsoy, M.
      Date
      2011
      Source Title
      Lasers in Medical Science
      Print ISSN
      0268-8921
      Volume
      26
      Issue
      5
      Pages
      699 - 706
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      In this study, a thulium (Tm:YAP) laser system was developed for brain surgery applications. As the Tm:YAP laser is a continuous-wave laser delivered via silica fibers, it would have great potential for stereotaxic neurosurgery with highest local absorption in the IR region. The laser system developed in this study allowed the user to set the power level, exposure time, and modulation parameters (pulse width and on-off cycles). The Tm:YAP laser beam (200-600 mW, 69-208 W/cm 2) was delivered from a distance of 2 mm to cortical and subcortical regions of ex-vivo Wistar rat brain tissue samples via a 200-μm-core optical fiber. The system performance, dosimetry study, and ablation characteristics of the Tm:YAP laser were tested at different power levels by maximizing the therapeutic effects and minimizing unwanted thermal side-effects. The coagulation and ablation diameters were measured under microscope. The maximum ablation efficiency (100 × ablation diameter/coagulation diameter) was obtained when the Tm:YAP laser system was operated at 200 mW for 10 s. At this laser dose, the ablation efficiency was found to be 71.4% and 58.7% for cortical and subcortical regions, respectively. The fiber-coupled Tm:YAP laser system in hence proposed for the delivery of photothermal therapies in medical applications. © 2011 Springer-Verlag London Ltd.
      Keywords
      1980-nm
      Ablation efficiency
      Brain tissue ablation
      Thulium laser
      glass fiber
      silicon dioxide
      animal tissue
      article
      brain cortex
      brain surgery
      brain tissue
      brain tissue ablation
      controlled study
      dosimetry
      ex vivo study
      gray matter
      infrared radiation
      laser
      microscope
      nonhuman
      on off cycle
      phototherapy
      physical parameters
      power level
      priority journal
      process optimization
      pulse width
      radiation absorption
      radiation dose
      radiation exposure
      rat
      stereotaxic surgery
      subcortex
      thermocoagulation
      thulium yttrium aluminum perovskite laser
      white matter
      Animals
      Brain
      Laser Therapy
      Rats
      Rats, Wistar
      Thulium
      Permalink
      http://hdl.handle.net/11693/21783
      Published Version (Please cite this version)
      http://dx.doi.org/10.1007/s10103-011-0915-0
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      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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