Development of a thulium (Tm:YAP) laser system for brain tissue ablation
Date
2011Source Title
Lasers in Medical Science
Print ISSN
0268-8921
Volume
26
Issue
5
Pages
699 - 706
Language
English
Type
ArticleItem Usage Stats
147
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views
165
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Abstract
In this study, a thulium (Tm:YAP) laser system was developed for brain surgery applications. As the Tm:YAP laser is a continuous-wave laser delivered via silica fibers, it would have great potential for stereotaxic neurosurgery with highest local absorption in the IR region. The laser system developed in this study allowed the user to set the power level, exposure time, and modulation parameters (pulse width and on-off cycles). The Tm:YAP laser beam (200-600 mW, 69-208 W/cm 2) was delivered from a distance of 2 mm to cortical and subcortical regions of ex-vivo Wistar rat brain tissue samples via a 200-μm-core optical fiber. The system performance, dosimetry study, and ablation characteristics of the Tm:YAP laser were tested at different power levels by maximizing the therapeutic effects and minimizing unwanted thermal side-effects. The coagulation and ablation diameters were measured under microscope. The maximum ablation efficiency (100 × ablation diameter/coagulation diameter) was obtained when the Tm:YAP laser system was operated at 200 mW for 10 s. At this laser dose, the ablation efficiency was found to be 71.4% and 58.7% for cortical and subcortical regions, respectively. The fiber-coupled Tm:YAP laser system in hence proposed for the delivery of photothermal therapies in medical applications. © 2011 Springer-Verlag London Ltd.
Keywords
1980-nmAblation efficiency
Brain tissue ablation
Thulium laser
glass fiber
silicon dioxide
animal tissue
article
brain cortex
brain surgery
brain tissue
brain tissue ablation
controlled study
dosimetry
ex vivo study
gray matter
infrared radiation
laser
microscope
nonhuman
on off cycle
phototherapy
physical parameters
power level
priority journal
process optimization
pulse width
radiation absorption
radiation dose
radiation exposure
rat
stereotaxic surgery
subcortex
thermocoagulation
thulium yttrium aluminum perovskite laser
white matter
Animals
Brain
Laser Therapy
Rats
Rats, Wistar
Thulium
Permalink
http://hdl.handle.net/11693/21783Published Version (Please cite this version)
http://dx.doi.org/10.1007/s10103-011-0915-0Collections
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