• About
  • Policies
  • What is openaccess
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Molecular Biology and Genetics
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Faculty of Science
      • Department of Molecular Biology and Genetics
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Ras family of proteins: Cellular function, molecular control, and its role in oncogenesis

      Thumbnail
      View / Download
      368.4 Kb
      Author
      Telkoparan, P.
      Tazebay, U. H.
      Date
      2011
      Source Title
      Turkish Journal of Biochemistry [Türk Biyokimya Dergisi]
      Print ISSN
      1303-829X
      Publisher
      Türk Biyokimya Derneği
      Volume
      36
      Issue
      4
      Pages
      367 - 373
      Language
      Turkish
      Type
      Article
      Item Usage Stats
      90
      views
      82
      downloads
      Abstract
      Small GTPases belonging to Ras family of proteins have key roles in regulating nearly every aspect of cell biology, such as cell division, cellular differentiation, vesicular transport and localization of cargo proteins, cell morphology, and gene expression. Depending on the extracellular signals, Ras family members oscillate between GTP-bound (active) and GDP-bound (inactive) conformations, and in the active form they interact with downstream effector molecules, leading to conformational changes in those effectors. As a result, extracellular signals trigger cellular responses, by means of initiation of a phosphorylation cascade. Functional cycles of Ras family of proteins include interactions with GTPase Activating Proteins (GAPs), and with Guanine Nucleotide Exchange Factors (GEFs) that regulate these small GTPases. GAP proteins activate intrinsic GTP hydrolysis activities of these small G-proteins, and convert active Ras-GTP to inactive Ras-GTP. On the other hand, GEF proteins interact with inactivated Ras-GDP molecules, and convert those inactivated molecules back to activated Ras-GTP, by triggering dissociation of GDP, and reassociation of Ras with GTP which is found at higher concentrations as compared to GDP in the cell cytoplasm. It is well known that mutations in Ras that block these molecules in GTP-bound forms by impairing GTP hydrolysis activity could trigger an uncontrolled and aberrant cellular proliferation. This type of mutations in Ras genes causing uncontrolled activation of the protein, are found in approximately 30% of human cancers overall, and they indicate the significance of mutations in genes encoding Ras family members in cellular proliferation related to de novo oncoge-nesis in human.
      Keywords
      Oncogenesis
      Ras family
      RasGAP
      RasGEF
      Small G-proteins
      Permalink
      http://hdl.handle.net/11693/21674
      Collections
      • Department of Molecular Biology and Genetics 460
      Show full item record

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartments

      My Account

      Login

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 1771
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy