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      Fiber laser-microscope system for femtosecond photodisruption of biological samples

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      Author(s)
      Yavaş, Seydi
      Erdoğan, Mutlu
      Gürel, Kutan
      İlday, F. Ömer
      Eldeniz, Y. B.
      Tazebay, Uygar H.
      Date
      2012-02-22
      Source Title
      Biomedical Optics Express
      Electronic ISSN
      2156-7085
      Publisher
      Optical Society of America
      Volume
      3
      Issue
      3
      Pages
      605 - 611
      Language
      English
      Type
      Article
      Item Usage Stats
      166
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      123
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      Abstract
      We report on the development of a ultrafast fiber lasermicroscope system for femtosecond photodisruption of biological targets. A mode-locked Yb-fiber laser oscillator generates few-nJ pulses at 32.7 MHz repetition rate, amplified up to ~125 nJ at 1030 nm. Following dechirping in a grating compressor, ~240 fs-long pulses are delivered to the sample through a diffraction-limited microscope, which allows real-time imaging and control. The laser can generate arbitrary pulse patterns, formed by two acousto-optic modulators (AOM) controlled by a custom-developed fieldprogrammable gate array (FPGA) controller. This capability opens the route to fine optimization of the ablation processes and management of thermal effects. Sample position, exposure time and imaging are all computerized. The capability of the system to perform femtosecond photodisruption is demonstrated through experiments on tissue and individual cells.
      Keywords
      Fiber lasers
      Field programmable gate arrays (FPGA)
      Mode-locked fiber lasers
      Tissue
      Ytterbium
      Ablation process
      Acousto-optic modulator
      Arbitrary pulse
      Biological samples
      Biological targets
      Dechirping
      Diffraction limited
      Exposure-time
      Femtoseconds
      Grating compressors
      Individual cells
      Mode-locked
      Photodisruption
      Realtime imaging
      Repetition rate
      Sample position
      Ultra-fast
      Yb fiber lasers
      Pulse generators
      Permalink
      http://hdl.handle.net/11693/21562
      Published Version (Please cite this version)
      http://dx.doi.org/10.1364/BOE.3.000605
      Collections
      • Advanced Research Laboratories (ARL) 35
      • Department of Molecular Biology and Genetics 468
      • Department of Physics 2397
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
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