Surface-adhesive and osteogenic self-assembled peptide nanofibers for bioinspired functionalization of titanium surfaces
3929 - 3937
MetadataShow full item record
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/21505
Mechanical properties and biological inertness of titanium provide potential in orthopedic and dental implants. However, integration of titanium-based implants into the existing tissue is a major problem. Herein, we demonstrate biofunctionalization of titanium surfaces through a mussel-inspired adhesion mechanism conjugated to self-assembled peptide nanofibers in order to overcome biocompatibility issues. A Dopa conjugated peptide nanofiber coating was used along with bioactive peptide sequences for osteogenic activity to enhance osseointegration of medical grade titanium surface, TiAl6V4 alloy. Dopa-mediated immobilization of osteogenic peptide nanofibers on titanium surfaces created an osteoconductive interface between osteoblast-like cells and inhibited adhesion and viability of soft tissue forming fibroblasts compared to the uncoated titanium substrate. This biofunctionalization strategy can be extended into other surface immobilization systems owing to the versatile adhesive properties of Dopa and the ease of ligand conjugation to peptide amphiphile molecules. © 2012 The Royal Society of Chemistry.
- Research Paper 7144
Showing items related by title, author, creator and subject.
Size-controlled conformal nanofabrication of biotemplated three-dimensional TiO2 and ZnO nanonetworks Ceylan H.; Ozgit-Akgun, C.; Erkal, T.S.; Donmez I.; Garifullin, R.; Tekinay, A.B.; Usta H.; Biyikli, N.; Guler, M.O. (2013)A solvent-free fabrication of TiO2 and ZnO nanonetworks is demonstrated by using supramolecular nanotemplates with high coating conformity, uniformity, and atomic scale size control. Deposition of TiO2 and ZnO on ...
Bone-like mineral nucleating peptide nanofibers induce differentiation of human mesenchymal stem cells into mature osteoblasts Ceylan H.; Kocabey, S.; Unal Gulsuner H.; Balcik O.S.; Guler, M.O.; Tekinay, A.B. (American Chemical Society, 2014)A bone implant should integrate to the tissue through a bone-like mineralized interface, which requires increased osteoblast activity at the implant-tissue boundary. Modification of the implant surface with synthetic ...
Garifullin R.; Eren H.; Ulusoy T.G.; Okyay A.K.; Biyikli N.; Guler M.O. (Wiley-VCH Verlag, 2016)Here peptide amphiphile (PA) nanofiber network is exploited as a three-dimensional soft template to construct anatase TiO2 and wurtzite ZnO nanonetworks. Atomic layer deposition (ALD) technique is used to coat the organic ...