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dc.contributor.authorAkkoç Köksal, M.en_US
dc.contributor.authorYüksel Yarım, M.en_US
dc.contributor.authorDurmaz, İremen_US
dc.contributor.authorAtalay Çetin, Rengülen_US
dc.date.accessioned2016-02-08T09:45:38Z
dc.date.available2016-02-08T09:45:38Z
dc.date.issued2012en_US
dc.identifier.issn1300-0527
dc.identifier.urihttp://hdl.handle.net/11693/21391
dc.description.abstractA series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H -indole derivatives were synthesized, and their structures were confirmed by spectral analysis. All the compounds were tested for their cytotoxic activity in vitro against 3 human tumor cell lines: human liver (HUH7), breast (MCF7), and colon (HCT116). Among the designed derivatives, most of the compounds showed significant cytotoxicity against liver and colon cancer cell lines with lower IC50 concentrations than the standard drug 5-fluorouracil. Compound 3s, with 3,4-dichlorophenyl substituent on the piperazine ring, was the most active in suppressing the growth of all screened cancer cells. © TÜBITAK.en_US
dc.language.isoEnglishen_US
dc.source.titleTurkish Journal of Chemistryen_US
dc.relation.isversionofhttps://doi.org/10.3906/kim-1111-5en_US
dc.subject1,4-substituted piperazinesen_US
dc.subjectAnticancer activityen_US
dc.subjectCytotoxicityen_US
dc.subjectIndoleen_US
dc.subjectMannich baseen_US
dc.titleDesign, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agentsen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage515en_US
dc.citation.epage525en_US
dc.citation.volumeNumber36en_US
dc.citation.issueNumber4en_US
dc.identifier.doi10.3906/kim-1111-5en_US
dc.contributor.bilkentauthorDurmaz, İrem
dc.contributor.bilkentauthorAtalay Çetin, Rengül


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