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dc.contributor.authorGurdal, E.E.en_US
dc.contributor.authorDurmaz I.en_US
dc.contributor.authorCetin-Atalay, R.en_US
dc.contributor.authorYarim, M.en_US
dc.date.accessioned2016-02-08T09:45:30Z
dc.date.available2016-02-08T09:45:30Z
dc.date.issued2015en_US
dc.identifier.issn14756366
dc.identifier.urihttp://hdl.handle.net/11693/21381
dc.description.abstractSynthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI<inf>50</inf> values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Compound 1d is highly cytotoxic against all tested cancer cell lines. Further investigation of compound 1d by Hoechst Staining and Fluorescence-Activated Cell Sorting Analysis (FACS) revealed that this compound causes apoptosis by cell cycle arrest at subG<inf>1</inf> phase. © 2014 Informa UK Ltd. All rights reserved.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.3109/14756366.2014.959513en_US
dc.subjectAnticanceren_US
dc.subjectbenzothiazoleen_US
dc.subjectcytotoxicityen_US
dc.subjectpiperazineen_US
dc.subjectsulphorodamine Ben_US
dc.subjectantineoplastic agenten_US
dc.subjectbenzothiazole derivativeen_US
dc.subjectfluorouracilen_US
dc.subjectn (6 ethoxybenzothiazol 2 yl) 2 [4 (o chlorophenyl)piperazinyl]acetamideen_US
dc.subjectn (6 ethoxybenzothiazol 2 yl) 2 [4 (o cyanophenyl)piperazinyl]acetamideen_US
dc.subjectn (6 ethoxybenzothiazol 2 yl) 2 [4 (p cyanophenyl)piperazinyl]acetamideen_US
dc.subjectn (6 ethoxybenzothiazol 2 yl) 2 [4 (p toluyl)piperazinyl]acetamideen_US
dc.subjectn (6 methylbenzothiazol 2 yl) 2 (4 cyclohexylpiperazinyl)acetamideen_US
dc.subjectn (6 methylbenzothiazol 2 yl) 2 [4 (2 methoxyethyl)piperazinyl]acetamideen_US
dc.subjectn (6 methylbenzothiazol 2 yl) 2 [4 (2 methoxyphenyl)piperazinyl]acetamideen_US
dc.subjectn (6 methylbenzothiazol 2 yl) 2 [4 (3,4 dichlorophenyl)piperazinyl]acetamideen_US
dc.subjectn (6 methylbenzothiazol 2 yl) 2 [4 (4 chlorobenzyl)piperazinyl]acetamideen_US
dc.subjectn (6 methylbenzothiazol 2 yl) 2 [4 (pyridin 4 yl)piperazinyl]acetamideen_US
dc.subjectpiperazine derivativeen_US
dc.subjectsulforhodamine Ben_US
dc.subjectunclassified drugen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectcancer cell lineen_US
dc.subjectcell cycle arresten_US
dc.subjectcell cycle G1 phaseen_US
dc.subjectchemical structureen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug cytotoxicityen_US
dc.subjectdrug synthesisen_US
dc.subjectfluorescence activated cell sortingen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjecthuman cell cultureen_US
dc.subjectin vitro studyen_US
dc.subjectpriority journalen_US
dc.subjectproton nuclear magnetic resonanceen_US
dc.titleCytotoxic activities of some benzothiazole-piperazine derivativesen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Genetics
dc.citation.spage649en_US
dc.citation.epage654en_US
dc.citation.volumeNumber30en_US
dc.citation.issueNumber4en_US
dc.identifier.doi10.3109/14756366.2014.959513en_US
dc.publisherTaylor and Francis Ltden_US


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