Cytotoxic activities of some benzothiazole-piperazine derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor and Francis Ltd
649 - 654
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Please cite this item using this persistent URLhttp://hdl.handle.net/11693/21381
Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI<inf>50</inf> values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Compound 1d is highly cytotoxic against all tested cancer cell lines. Further investigation of compound 1d by Hoechst Staining and Fluorescence-Activated Cell Sorting Analysis (FACS) revealed that this compound causes apoptosis by cell cycle arrest at subG<inf>1</inf> phase. © 2014 Informa UK Ltd. All rights reserved.