Selective photosensitization through an and logic response : optimization of the pH and glutathione response of activatable photosensitizers
Cakmak, F. P.
Topel, S. D.
Uyar, T. B.
Akkaya, E. U.
1359-7345 (print)1364-548X (online)
Royal Society of Chemistry
12258 - 12261
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Please cite this item using this persistent URLhttp://hdl.handle.net/11693/21347
A series of pH and GSH responsive photosensitizers were designed and synthesized. pK<inf>a</inf> values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.