Selective photosensitization through an and logic response: optimization of the pH and glutathione response of activatable photosensitizers
Royal Society of Chemistry
12258 - 12261
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A series of pH and GSH responsive photosensitizers were designed and synthesized. pK<inf>a</inf> values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.