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      Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats

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      Author
      Molina, D. P.
      Ariwodola, O. J.
      Linville, C.
      Sonntag, W. E.
      Weiner, J. L.
      Brunso-Bechtold, J. K.
      Adams, Michelle M.
      Date
      2012
      Source Title
      Neurobiology of Aging
      Print ISSN
      0197-4580
      Publisher
      Elsevier
      Volume
      33
      Issue
      9
      Pages
      1938 - 1949
      Language
      English
      Type
      Article
      Item Usage Stats
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      122
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      Abstract
      Alterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPA-R) and N-methyl-D-aspartate receptor (NMDA-R) have been documented in aged animals and may contribute to changes in hippocampal-dependent memory. Growth hormone (GH) regulates AMPA-R and NMDA-R-dependent excitatory transmission and decreases with age. Chronic GH treatment mitigates age-related cognitive decline. An in vitro CA1 hippocampal slice preparation was used to compare hippocampal excitatory transmission and plasticity in old animals treated for 6-8 months with either saline or GH. Our findings indicate that GH treatment restores NMDA-R-dependent basal synaptic transmission in old rats to young adult levels and enhances both AMPA-R-dependent basal synaptic transmission and long-term potentiation. These alterations in synaptic function occurred in the absence of changes in presynaptic function, as measured by paired-pulse ratios, the total protein levels of AMPA-R and NMDA-R subunits or in plasma or hippocampal levels of insulin-like growth factor-I. These data suggest a direct role for GH in altering age-related changes in excitatory transmission and provide a possible cellular mechanism through which GH changes the course of cognitive decline. © 2012 Elsevier Inc.
      Keywords
      Long-term potentiation
      Paired-pulse ratios
      Input-output curves
      AMPA receptor
      NMDA receptor
      Permalink
      http://hdl.handle.net/11693/21345
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.neurobiolaging.2011.09.014
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      • Aysel Sabuncu Brain Research Center (BAM) 183
      • Department of Psychology 157
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