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      Supramolecular chirality in self-assembled peptide amphiphile nanostructures

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      Author
      Garifullin, R.
      Güler, Mustafa O.
      Date
      2015
      Source Title
      Chemical Communications
      Print ISSN
      1359-7345
      Publisher
      Royal Society of Chemistry
      Volume
      51
      Issue
      62
      Pages
      12470 - 12473
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Induced supramolecular chirality was investigated in the self-assembled peptide amphiphile (PA) nanosystems. Having shown that peptide chirality can be transferred to the covalently-attached achiral pyrene moiety upon PA self-assembly, the chiral information is transferred to molecular pyrene via weak noncovalent interactions. In the first design of a supramolecular chiral system, the chromophore was covalently attached to a peptide sequence (VVAGH) via an ε-aminohexanoic acid spacer. Covalent attachment yielded a PA molecule self-assembling into nanofibers. In the second design, the chromophore was encapsulated within the hydrophobic core of self-assembled nanofibers of another PA consisting of the same peptide sequence attached to lauric acid. We observed that supramolecular chirality was induced in the chromophore by PA assembly into chiral nanostructures, whether it was covalently attached, or noncovalently bound.
      Keywords
      Aminocaproic acid derivative
      Amphophile
      Lauric acid
      Nanofiber
      Nanomaterial
      Nanoribbon
      Peptide derivative
      Absorption
      Amino acid sequence
      Article
      Chirality
      Circular dichroism
      Covalent bond
      Encapsulation
      Isomer
      Peptide synthesis
      Solid phase synthesis
      Solubilization
      Permalink
      http://hdl.handle.net/11693/21336
      Published Version (Please cite this version)
      http://dx.doi.org/10.1039/c5cc04982b
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      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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