Cd81 Interacts with the T Cell Receptor to Suppress Signaling
MetadataShow full item record
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/21250
CD81 (TAPA-1) is a ubiquitously expressed tetraspanin protein identified as a component of the B lymphocyte receptor (BCR) and as a receptor for the Hepatitis C Virus. In an effort to identify trans-membrane proteins that interact with the T-cell antigen receptor (TCR), we performed a membrane yeast two hybrid screen and identified CD81 as an interactor of the CD3delta subunit of the TCR. We found that in the absence of CD81, in thymocytes from knockout mice, TCR engagement resulted in stronger signals. These results were recapitulated in T cell lines that express low levels of CD81 through shRNA mediated silencing. Increased signaling did not result from alterations in the levels of TCR on the surface of T lymphocytes. Although CD81 is not essential for normal T lymphocyte development, it plays an important role in regulating TCR and possibly pre-TCR signal transduction by controlling the strength of signaling. CD81 dependent alterations in thymocyte signaling are evident in increased CD5 expression on CD81 deficient double positive (DP) thymocytes. We conclude that CD81 interacts with the T cell receptor to suppress signaling. © 2012 Cevik et al.
Showing items related by title, author, creator and subject.
Involvement of sting-activating cyclic Di-nucleotides on T-cell differentiation and function: An unresolved issue [Sting’i etkinleştiren siklik dinükleotidlerin T hücre diferansiyasyonu ve fonksiyonuna olan etkisi: Çözülmemiş bir sorun] Yıldız B.; Gürsel İ. (Turkish Society of Immunology, 2016)STING is the pivotal mediator for the recognition of host and pathogenic cytosolic dsDNA as well as cyclic di-nucleotide metabolites from microbes. Studies demonstrated that DNA released from cancerous cells are internalized ...
Cekic, C.; Linden J. (American Association for Cancer Research Inc., 2014)Adenosine A2A receptor (A2AR) blockade enhances innate and adaptive immune responses. However, mouse genetic studies have shown that A2AR deletion does not inhibit the growth of all tumor types. In the current study, we ...
Impaired toll like receptor-7 and 9 induced immune activation in chronic spinal cord injured patients contributes to immune dysfunction Gucluler G.; Adiguzel E.; Gungor B.; Kahraman T.; Gursel M.; Yilmaz B.; Gursel I. (Public Library of Science, 2017)Reduced immune activation or immunosuppression is seen in patients withneurological diseases. Urinary and respiratory infections mainly manifested as septicemia and pneumonia are the most frequent complications following ...