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dc.contributor.authorZhang, Y.en_US
dc.contributor.authorKyle J.R.en_US
dc.contributor.authorPenchev, M.en_US
dc.contributor.authorYazdanpanah V.en_US
dc.contributor.authorYu J.en_US
dc.contributor.authorLi, Y.en_US
dc.contributor.authorYang, M.en_US
dc.contributor.authorBudak G.en_US
dc.contributor.authorÖzbay, Ekmelen_US
dc.contributor.authorOzkan, M.en_US
dc.contributor.authorOzkan, C.S.en_US
dc.date.accessioned2016-02-08T09:43:06Z
dc.date.available2016-02-08T09:43:06Z
dc.date.issued2012en_US
dc.identifier.issn21911630
dc.identifier.urihttp://hdl.handle.net/11693/21210
dc.description.abstractCellular uptake behavior of iron oxide nanoparticles is investigated using a transmission near-field scanning optical microscopy (NSOM) without the need of fluorescent labeling. By using the transmission NSOM system, we could simultaneously explore the near-field optical analysis of the cell interior and record the topographic information of the cell surface. The cell endocytosis of iron oxide nanoparticles by normal breast MCF10A cells is first studied by this transmission NSOM system, and this dual functional nanoscale-resolution microscopy shows the capability of mapping the spatial localization of nanoparticles in/outside cell surface without the need of fluorescence labeling. Nanoscale optical signature patterns for iron oxide nanoparticle-loaded vesicles inside the cells were observed and analyzed. © Springer Science+Business Media, LLC 2012.en_US
dc.language.isoEnglishen_US
dc.source.titleBioNanoScienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s12668-012-0043-8en_US
dc.subjectAFMen_US
dc.subjectEndocytosisen_US
dc.subjectIron oxideen_US
dc.subjectMCF10Aen_US
dc.subjectNanoparticleen_US
dc.subjectNSOMen_US
dc.subjectAFMen_US
dc.subjectEndocytosisen_US
dc.subjectFluorescence labelingen_US
dc.subjectFluorescent labelingen_US
dc.subjectIron oxide nanoparticleen_US
dc.subjectMCF10Aen_US
dc.subjectSpatial localizationen_US
dc.subjectTopographic informationen_US
dc.subjectCell membranesen_US
dc.subjectCytologyen_US
dc.subjectFluorescenceen_US
dc.subjectIron oxidesen_US
dc.subjectMetal nanoparticlesen_US
dc.subjectMolecular biologyen_US
dc.subjectNanoparticlesen_US
dc.subjectNanotechnologyen_US
dc.subjectNear field scanning optical microscopyen_US
dc.subjectfluorescent dyeen_US
dc.subjectiron oxideen_US
dc.subjectnanoparticleen_US
dc.subjectarticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdetoxificationen_US
dc.subjectdrug delivery systemen_US
dc.subjectdrug uptakeen_US
dc.subjectendocytosisen_US
dc.subjectfluorescenceen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectkineticsen_US
dc.subjectlight scatteringen_US
dc.subjectnuclear magnetic resonance imagingen_US
dc.subjectpolarimetryen_US
dc.subjectscanning electron microscopyen_US
dc.subjectscanning near field optical microscopyen_US
dc.subjecttissue repairen_US
dc.subjecttopographyen_US
dc.subjectzeta potentialen_US
dc.titleTransmission Near-Field Scanning Optical Microscopy Investigation on Cellular Uptake Behavior of Iron Oxide Nanoparticlesen_US
dc.typeArticleen_US
dc.departmentNANOTAM - Nanotechnology Research Center
dc.departmentDepartment of Physics
dc.citation.spage135en_US
dc.citation.epage143en_US
dc.citation.volumeNumber2en_US
dc.citation.issueNumber3en_US
dc.identifier.doi10.1007/s12668-012-0043-8en_US
dc.contributor.bilkentauthorÖzbay, Ekmelen_US


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