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      Transmission Near-Field Scanning Optical Microscopy Investigation on Cellular Uptake Behavior of Iron Oxide Nanoparticles

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      Author
      Zhang, Y.
      Kyle J.R.
      Penchev, M.
      Yazdanpanah V.
      Yu J.
      Li, Y.
      Yang, M.
      Budak G.
      Özbay, Ekmel
      Ozkan, M.
      Ozkan, C.S.
      Date
      2012
      Source Title
      BioNanoScience
      Print ISSN
      21911630
      Volume
      2
      Issue
      3
      Pages
      135 - 143
      Language
      English
      Type
      Article
      Item Usage Stats
      149
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      125
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      Abstract
      Cellular uptake behavior of iron oxide nanoparticles is investigated using a transmission near-field scanning optical microscopy (NSOM) without the need of fluorescent labeling. By using the transmission NSOM system, we could simultaneously explore the near-field optical analysis of the cell interior and record the topographic information of the cell surface. The cell endocytosis of iron oxide nanoparticles by normal breast MCF10A cells is first studied by this transmission NSOM system, and this dual functional nanoscale-resolution microscopy shows the capability of mapping the spatial localization of nanoparticles in/outside cell surface without the need of fluorescence labeling. Nanoscale optical signature patterns for iron oxide nanoparticle-loaded vesicles inside the cells were observed and analyzed. © Springer Science+Business Media, LLC 2012.
      Keywords
      AFM
      Endocytosis
      Iron oxide
      MCF10A
      Nanoparticle
      NSOM
      AFM
      Endocytosis
      Fluorescence labeling
      Fluorescent labeling
      Iron oxide nanoparticle
      MCF10A
      Spatial localization
      Topographic information
      Cell membranes
      Cytology
      Fluorescence
      Iron oxides
      Metal nanoparticles
      Molecular biology
      Nanoparticles
      Nanotechnology
      Near field scanning optical microscopy
      fluorescent dye
      iron oxide
      nanoparticle
      article
      controlled study
      detoxification
      drug delivery system
      drug uptake
      endocytosis
      fluorescence
      human
      human cell
      kinetics
      light scattering
      nuclear magnetic resonance imaging
      polarimetry
      scanning electron microscopy
      scanning near field optical microscopy
      tissue repair
      topography
      zeta potential
      Permalink
      http://hdl.handle.net/11693/21210
      Published Version (Please cite this version)
      http://dx.doi.org/10.1007/s12668-012-0043-8
      Collections
      • Department of Physics 2299
      • Nanotechnology Research Center (NANOTAM) 1006
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